ea0098c28 | Clinical – Nuclear Medicine/Interventional Radiology/Imaging | NANETS2023
Chauhan Aman
, Kolesar Jill
, Yan Donglin
, Li Daneng
, Khurana Aman
, Edgar Carson William
, Arnold Susanne M.
, Gore Steven
, Rubinstein Larry
, Kohn Elise C.
, Percy Ivy S.
, Xiao Ying
, Dewaraja Yuni
, Soares Heloisa P.
, Hendrik Beumer Jan
, Konda Bhavana
, Sukrithan Vineeth
, Brian Anthony Lowell
Background: Radiolabeled somatostatin analogs provide a means of delivering targeted radiation with a high therapeutic index to NETs that express somatostatin receptors (SSTRs). We hypothesize that the addition of an effective radiation sensitizer could help improve the antitumor activity of Lutathera. Radiation is a potent inducer of DNA damage. The primary repair mechanism of radiation-induced double-stranded breaks (DSBs) is the nonhomologous end-joining (NHEJ) pathway, in ...