Searchable abstracts of presentations at key conferences in endocrinology

ea0028p13 | Bone | SFEBES2012

Osteoporosis in healthy South Indian males: the influence of life style factors and vitamin D status

Asha H , Prabhu Suresh , Paul Thomas , Seshadri M

Osteoporosis in men is increasingly being recognized as a public health issue. Thirty percent of hip fractures occur in men, and one in eight fractures occurs in men above 50 years of age.Objectives: To assess the prevalence of osteoporosis in healthy male subjects using Bone Mineral Density (BMD) as measured by Dual energy X-ray absorptiometry (DXA), and to study the influence of various factors which influence BMD.Methods: Health...

ea0034p27 | Bone | SFEBES2014

The diagnosis of osteoporosis among South Indian male and female subjects with low impact hip fracture and comparison between Indian Council of Medical Research and Caucasian Bone Mineral Density Databases

Thomas Nihal , Shetty Sahana , Kapoor Nitin , Asha H S , Naik Dukhabandhu , Visalakshi P , Paul Thomas

Aims and objectives: This study was undertaken to look at the agreement between the hologic database (HD) based on NHANES bone mineral density (BMD) data in Caucasians and the ICMR database (ICMRD) published in 2010 in defining normal and subnormal BMD in subjects with or without hip fracture and to arrive at a BMD cut off which has a high sensitivity of predicting fracture.Materials and methods: A cross sectional study of 3098 subjects (men-341 and wome...

ea0034p135 | Clinical practice/governance and case reports | SFEBES2014

Next generation sequencing approach for molecular genetic diagnosis of familial partial lipodystrophy

Thomas Nihal , Asha H S , Chapla Aaron , Manika V , Shetty Shrinath

Background: Familial partial lipodystrophy type 2 (FPLD2) is an autosomal dominant inherited form of lipodystrophy due to mutation in the LMNA gene on chromosome 1q22. It is characterized by selective loss of subcutaneous adipose tissue from the limbs and trunk, with accumulation of fat in the neck and face, insulin resistance, diabetes mellitus and dyslipidemia.Objective: To study the clinical features and establish the molecular diagnosis of two subjec...

ea0034p270 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

Does TCF7L2 polymorphisms increase the risk of gestational diabetes mellitus in South Indian population?

Thomas Nihal , Mahesh D M , Chapla Aaron , Paul Johan , Shwetha N , Christina Flory , Asha H S

Introduction: Genetic predisposition with environmental factors plays a significant role in the development of type 2 diabetes mellitus. Among the diabetogenic genes, the transcription factor 7-like 2 (TCF7L2), a member of the Wnt signalling pathway remains the strongest genetic determinant of type 2 diabetes risk in humans. Our aim was to investigate whether TCF7L2 variants that have previously been associated with type2 diabetes would also confer risk for gestational diabete...

ea0028p16 | Bone | SFEBES2012

A study of vitamin D status and Bone Mineral Density in epileptic patients from South India

Koshy George , Paul Thomas , Asha H , Thomas Nihal , Aaron Sanjit , Thomas Maya , Alexander Mathew , Seshadri M

Introduction: There are many reports describing the association of alternations of bone and mineral metabolism in patients with epilepsy receiving long term anticonvulsant therapy. However, there are only a few Indian studies which have looked at this aspect. Objective: This study was done to compare the prevalence of changes in bone mineral parameters and bone mineral density (BMD) in ambulant individuals on long term anticonvulsant therapy with age and BMI matched healthy co...

ea0034p136 | Clinical practice/governance and case reports | SFEBES2014

The H-syndrome and next generation sequencing for molecular genetic diagnosis

Thomas Nihal , Mahesh D M , Chapla Aaron , Asha H S , Shetty Shrinath , Shetty Sahana , Lydia M , George Renu

Background: The H-syndrome is a recently described very rare monogenic systemic autoinflammatory autosomal-recessive genodermatosis with young onset of diabetes without evidence of autoimmunity. It is caused by mutations in the SLC29A3 gene, which encodes the equilibrative nucleoside transporter hENT3.Objectives: To study the clinical features and confirm the genetic diagnosis in a subject with young onset of diabetes.Subject and m...

ea0028p42 | Clinical practice/governance and case reports | SFEBES2012

Endoscopic ultrasonography is a sensitive tool in the preoperative localization of insulinoma

Joseph A , Kapoor Nitin , Asha H , Simon Ebby , Chacko Ashok , Thomas Elsa , Eapen Anu , Ramakrishna Banumathi , Abraham Deepak , Paul M , Paul Thomas , Thomas Nihal , Rajaratnam Simon

Introduction: Various imaging modalities are used in the preoperative localization of insulinoma. CT is the modality that is in widespread use. Endoscopic ultrasound (EUS) allows the transducer to be placed in close proximity to the pancreas, thereby yielding images of higher quality, leading to accurate localization. An accurate preoperative localization results in a minimal invasive surgery and less occurrence of residual tumors, translating into a better clinical outcome. O...

ea0038p77 | Clinical practice/governance and case reports | SFEBES2015

Phaeochromocytoma: experience from a single centre in South India

Naik Dukhabandhu , Das Gupta Riddhi , Asha H S , Paul Thomas V , Kapoor Nitin , Mahesh D M , Cherian Anish Jacob , Abraham Deepak T , Shanthly Nylla , Oomen Reji , Chandramohan Anuradha , Ramakrishna Banumathi , Pai Rekha , Paul M J , Rajaratnam Simon , Thomas Nihal

Phaeochromocytoma (PCC) and paragangliomas (PGL) are neuroendocrine tumours derived from the embryonic neural crest, located either within the adrenal gland or at extra-adrenal sites.Objective: To study the clinical, biochemical, imaging characteristics, and mutational profile of patients with PCC/PGL treated at our institution.Methods: We collected data of patients with PCC/PGLs managed at Christian Medical College, Vellore, India...

ea0038p101 | Clinical practice/governance and case reports | SFEBES2015

A complex case of MEN1

Naik Dukhabandhu , Mahesh D M , Asha H S , Abraham Deepak T , Shanthly Nylla , Chandramohan Anuradha , Burad Deepak , Ramakrishna Banumathi , Paul M J , Kapoor Nitin , Paul Thomas , Chacko Ari G , Thomas Nihal

Objective: We report the rare case of a 45-year-old male with multiple endocrine neoplasm 1 (MEN1) with simultaneous occurrence characteristic tumours leading to a delicately balanced metabolic homeostasis.Methods: Clinical, biochemical, and radiological data of this patient diagnosed to have MEN1 were analysed and the challenges in the management of these neuroendocrine tumours are discussed.Case illustration: A 45-year-old gentle...

ea0038p271 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Evaluation of hypoglycaemia unawareness in individuals with type 1 diabetes mellitus using continuous glucose monitoring in a tertiary care centre

Naik Dukhabandhu , Shilpa R M , Mahesh D M , Asha H S , Kapoor Nitin , Paul Thomas , Padmanabhan V , Inbakumari Mercy , Christina Flory , Rani Jansi , Natarajan Divya , Jeyaseelan L , Thomas Nihal

Background: Intensive glycemic control forms the benchmark of management of type 1 diabetes mellitus (T1DM) and is limited by the risk of hypoglycaemia. Repeated episodes of hypoglycaemia can lead to development of hypoglycaemia unawareness and a sixfold increase in deaths in those experiencing severe hypoglycaemia. Severe hypoglycaemia occurs in 35–42% patients with T1DM. However, there is lack of data from our population and hence we aimed to objectively estimate the pr...