Searchable abstracts of presentations at key conferences in endocrinology

ea0038p421 | Steroids | SFEBES2015

Iatrogenic Cushing’s syndrome secondary to combined oral contraceptive pill in a patient with congenital adrenal hyperplasia

Artham Satish , Mamoojee Yaasir , Ashwell Simon

Introduction: Congenital Adrenal Hyperplasia (CAH) is a rare genetic disorder characterised by deficiency of cortisol and/or mineralocorticoid hormones with over production of sex steroids. 21-hydroxylase deficiency is the commonest cause of CAH accounting for 95% of cases. Severe form of classic CAH occurs in 1 in 15 000 live births.Case report: A 30 year old women with CAH diagnosed at birth was on replacement with hydrocortisone and fludrocortisone. S...

ea0021p379 | Thyroid | SFEBES2009

The safety and efficacy of iopanoic acid in the pre-surgical management of thyrotoxicosis

Erukulapati Ravi Sankar , Mada Srikanth , Ashwell Simon

Background: Iopanoic acid is an iodinated oral cholecystographic contrast agent, which can be used for the rapid blockade of thyroid hormone production in preparation for thyroidectomy, especially in patients who are intolerant of thionamides. However, appropriate timing of thyroid surgery is vital.Project: In this retrospective audit, we identified all patients with thyrotoxicosis who received pre-operative preparation with iopanoic acid from 2006 to 20...

ea0037ep265 | Calcium and Vitamin D metabolism | ECE2015

Severe refractory hypocalcaemia associated with osteoblastic metastatic breast carcinoma

Lal Vikram , Ashwell Simon , Humphreys Alison , Nag Sath

Introduction: Hypercalcaemia is well associated with metastatic malignancy. Hypocalcaemia is an uncommon complication of osteoblastic metastases and occurs most commonly with breast and prostate carcinoma.Case: A 46-year-old woman with metastatic breast carcinoma and osteoblastic skeletal metastases treated with denosumab presented with severe symptomatic hypocalcaemia. Serum calcium was persistently low with a nadir value of 1.45 mmol/l (2.2–2.6) a...

ea0034p343 | Steroids | SFEBES2014

A large retrospective audit of adrenal incidentalomas

Zhyzhneuskaya Sviatlana , Wuerdemann Nora , Nag Sath , Arutchelvam Vijayaraman , Ashwell Simon

Objective: To determine whether people with an incidentally discovered adrenal mass are investigated according to regional and global standards (AACE guidelines); to determine the frequency of autonomous endocrine function.Methods: We did a retrospective analysis of clinical, pathology, and radiology records from January 2007 to December 2011. Patients were included if they were seen in the outpatient clinic for evaluation of an adrenal mass >1 cm in...

ea0032p550 | Endocrine tumours and neoplasia | ECE2013

Steroid-induced psychosis as a manifestation of ectopic ACTH secretion from metastatic poorly differentiated neuroendocrine tumour

Zhyzhneuskaya Sviatlana , Mukhtar Rasha , Ashwell Simon , Nag Sath

Case report: A 65-year-old fisherman presented with altered mental status, agitation, generalised oedema, dyspnoea, liver impairment and severe persistent hypokalaemia (2.2 mmol/l). History: COPD, IPF (on steroids since May 2012), ex-smoker. Physical examination: deeply tanned, Cushingoid facies, severe proximal myopathy. Medications prior to admission: prednisolone 40 mg OD, furosemide 40 mg OD, inhalers, and lansoprazole. In a view of clinical and biochemical features of ste...

ea0028p52 | Clinical practice/governance and case reports | SFEBES2012

The cost, efficacy and safety of Omnitrope compared with Genotropin in adults with growth hormone deficiency

Ullah Arif , Peacock Helen , Arutchelvam Vijayaraman , Nag Sath , Ashwell Simon

Omnitrope is a biosimilar growth hormone (GH) preparation with a lower acquisition cost than other GH preparations. We switched adult patients with growth hormone deficiency treated with Genotropin (n=14, age 59.2±13.7 [mean±SD] yrs, 8 male) to Omnitrope at an equivalent dose. There followed titration visits every month for 3 months then visits every 3 months until 9 months. GH dose (0.5±0.0 vs 0.5±0.0 mg [mean±SD],...

ea0028p123 | Clinical practice/governance and case reports | SFEBES2012

Primary adrenal lymphoma – an unusual case of hypoadrenalism with adrenal masses fluctuating in size

Swiecicka Agnieszka , Arutchelvam Vijayaraman , Siddaramaiah Naveen , Ashwell Simon , Nag Sath

A 66-year-old HIV positive male presented to gastroeneterologist with a 2 months history of severe fatigue, weight loss, dizziness and nausea. He had background of ulcerative colitis which was quiescent and he has not received steroids for more than 12 months. Baseline blood results revealed normal biochemistry with mild normocytic anaemia, neutropaenia and lymphopaenia. As there was a high clinical suspicion of adrenal insufficiency, the short synacthen test was performed whi...

ea0019p347 | Thyroid | SFEBES2009

Misdiagnosed thyrotoxicosis

Erukulapati Ravi Sankar , Mada S , Rao P , Ashwell Simon

Case report: A 76-year-old lady was referred to our Endocrinology department due to general malaise and abnormal thyroid function tests: TSH 1.1 (0.3–4.2) mU/l, fT4 30.6 (12.0–23.0) pmol/l, fT3 8.3 (4.0–7.8) pmol/l. She had received 131I twice, 16 and 36 years previously, at different hospitals for presumed thyrotoxicosis. She was clinically euthyroid and had a small diffuse goitre.Repeat thyroid function t...

ea0086p310 | Adrenal and Cardiovascular | SFEBES2022

Pheochromocytoma masquerading as acute coronary syndrome

Awadelkareem Abuzar , Elsaify Wael , Nag Sath , Ashwell Simon , Mohammed Azmi

Pheochromocytoma is a rare catecholamine-secreting tumor. It is potentially curable but can cause life-threatening hypertension or cardiac arrhythmias. We report a 58- years- old woman with no significant past medical history who was admitted through the emergency department with complaints of chest pain, palpitation, and nausea. She reported six months history of episodic palpitation and throbbing headaches, sometimes associated with light-headedness and dizziness. Hence, she...

ea0028p92 | Clinical practice/governance and case reports | SFEBES2012

The utility and impact of a joint thyroid clinic

Ashwell Simon , Trurun Peter , Potter Lewis , El-Saify Wael , Durning Patricia

A joint thyroid clinic (JTC) was established in February 2007 with the aim of improving the care of patients in whom an endocrine surgical opinion was required. The monthly clinic is attended by a Consultant Endocrinologist and a Consultant Endocrine Surgeon who together assess patients with thyroid, parathyroid and adrenal problems. Using retrospective case record analysis, we aimed to assess the impact of the clinic by studying the care of people referred with thyrotoxicosis...