Searchable abstracts of presentations at key conferences in endocrinology

ea0063p196 | Diabetes, Obesity and Metabolism 1 | ECE2019

Type 1 diabetic patients with more than five years of disease have increased global methylation levels

Duarte Guilherme CK , Assmann Tais S , Alves Melissa D , Rossoni Elis A , Correa Nathalia RF , Bauer Andrea C , Bossardi Ramon , Crispim Daisy

Background and aims: Type 1 diabetes mellitus (T1DM) results from a severe autoimmune destruction of pancreatic beta cells, which renders patients insulin-dependent for life. The triggering of autoimmunity against beta cells is caused by a complex interaction between environmental, genetic and epigenetic risk factors. Although significant progress has been made in elucidating the genetic factors associated with T1DM, the non-genetic components have remained poorly understood. ...

ea0049ep457 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

The T allele of the rs1746661G/T polymorphism in FNDC5 (irisin) gene is associated with increased systolic blood pressure

Brondani Leticia A. , Boucas Ana Paula , Assmann Tais S. , Reichelt Angela J. , Martins-Costa Sergio , Weinert Leticia S. , Silveiro Sandra P. , de Souza Bianca M. , Crispim Daisy

Background: Gestational diabetes mellitus (GDM) is a risk factor for type 2 diabetes and both conditions are characterized by insulin resistance (IR) and decreased insulin production by pancreatic beta-cells. FNDC5 gene encodes a type I membrane protein that is proteolytically processed to form a hormone secreted into the blood, termed irisin. After induction by exercise, irisin activates profound changes in the subcutaneous adipose tissue, stimulating browning and UCP1 gene e...