Searchable abstracts of presentations at key conferences in endocrinology

ea0016p197 | Diabetes and cardiovascular diseases | ECE2008

Circulating Reg1-α plasma levels: potential marker of beta cell regeneration?

Guglielmi Chiara , Battistoni Fabrizio , Valente Luciana , Astorri Elisa , Pitocco Dario , Pozzilli Paolo

Reg and Reg-related genes are members of a multifunctional family. Under physiological conditions Reg protein is not expressed in pancreatic beta cells, although the Reg protein receptor is expressed. When islets are damaged, the expression of Reg gene is increased in the islets of Langherans. In type 1 diabetes (T1D), insulin secretion may be still detectable in some subjects with long-standing disease indicating the existence of a small population of surviving beta cells or ...