Searchable abstracts of presentations at key conferences in endocrinology

ea0090s5.3 | Prolactinomas | ECE2023

Alternative medical treatments for prolactinomas

Auriemma Renata Simona

Dopamine agonists (DA), mainly cabergoline, are nowadays recommended as the treatment of choice for patients with prolactinomas of any size to lower PRL levels, decrease tumour size, and restore gonadal function. However, some patients do not adequately respond to DA, and resistance to DA may occur in 20-30% of patients treated with bromocriptine and nearly 10-20% of those receiving cabergoline. In these patients, multimodal therapy, including surgery and/or radiotherapy, may ...

ea0026p655 | Clinical case reports | ECE2011

Impact of two novel mutations of calcium sensing receptor (CaSR) gene on calcium metabolism: two clinical case reports

Livadariu Elena , Auriemma Renata Simona , Rydlewski Catherine , Vandeva Silvia , Thonnard Anne Sophie , Betea Daniela , Daly Adrian F , Beckers Albert

Disorders of calcium metabolism arise in a familial or sporadic setting. The resulting hypo- or hypercalcemia can induce serious clinical features. Calcium sensing receptor (CaSR) plays a key role in maintaining this balance and its molecular investigation is useful to determine the nature of a certain condition or to choose the appropriate therapeutic approach.In the present study we reported two clinical cases. A 16-year-old patient had a mild hypercal...

ea0063gp252 | Disturbances of Reproduction | ECE2019

Prolactin and prostate: an observational case-control study in men with prolactinoma under cabergoline treatment

Garifalos Francesco , De Alcubierre Dario , Verde Nunzia , Menafra Davide , Arnesi Mauro , de Angelis Cristina , Colao Annamaria , Auriemma Renata Simona , Pivonello Rosario

Prolactin (PRL) exerts independent hypertrophic effects on prostate in in vivo and in vitro experimental models, and prostatic PRL receptors are known to activate cell proliferation pathways such as MAPK and STAT. Nevertheless, in men with hyperprolactinemia the risk of prostate cancer has been found reduced suggesting a role of concomitant hypogonadism. Chronic cabergoline treatment generally normalizes PRL treatment and improves gonadal function. The curren...

ea0049gp184 | Pituitary | ECE2017

Hormonal and metabolic effects of long-term cabergoline withdrawal in patients with hyperprolactinemia

Auriemma Renata Simona , Blasio Chiara , Grasso Ludovica Francesca Stella , Galdiero Mariano , Negri Mariarosaria , Pivonello Claudia , Granieri Luciana , Colao Annamaria , Pivonello Rosario

Hyperprolactinemia is associated with abnormalities in glucose and lipid profile with development of insulin resistance and metabolic syndrome (MetS), which have been found to be improved by treatment with cabergoline (CAB). The current study aimed at investigating hormonal and metabolic effects of long-term CAB withdrawal in patients with prolactinomas. In 46 patients (37 F, 9 M, aged 34.5±11.5 yrs, 36 microadenomas and 10 macroadenomas) anthropometric (weight, BMI, wais...

ea0049ep34 | Adrenal cortex (to include Cushing's) | ECE2017

The treatment with dual release hydrocortisone in patients with adrenal insufficiency: correlation between change of the evening cortisol exposure time profile and change in metabolic profile, depression status and quality of life

Simeoli Chiara , Ferrigno Rosario , Pivonello Claudia , Auriemma Renata Simona , Negri Mariarosaria , Di Gennaro Gilda , Iacuaniello Davide , De Martino Maria Cristina , Colao Annamaria , Pivonello Rosario

Conventional glucocorticoids (CGCs) are unable to mimic physiological cortisol rhythm in adrenal insufficiency (AI), resulting in increased metabolic morbidity and impaired quality of life (QoL). Non-physiological cortisol pattern and elevated evening cortisol levels may be responsible for the increased risk of metabolic disorders observed in AI patients under CGCs. Once daily dual-release-hydrocortisone (DR-HC), which better reproduces physiological daily cortisol profile, si...

ea0041gp17 | Adrenal (1) | ECE2016

Improved evening and nocturnal cortisol exposure time profile in patients with adrenal insufficiency treated with dual release hydrocortisone: correlation with improvement in metabolic profile

Simeoli Chiara , Ferrigno Rosario , De Martino Maria Cristina , Auriemma Renata Simona , Pivonello Claudia , Negri Mariarosaria , Iacuaniello Davide , Di Gennaro Gilda , Colao Annamaria , Pivonello Rosario

Conventional glucocorticoids (GCs) are unable to mimic physiological cortisol rhythm in adrenal insufficiency (AI), with a significant impact on morbidity and mortality. Possible explanations are supra-physiological doses and impaired cortisol profile. In particular, elevated evening cortisol levels were related to glucose tolerance and insulin sensitivity alterations and visceral obesity. Once-daily-dual-release-hydrocortisone (OD-DR-HC), better reproducing the physiological ...

ea0026p298 | Pituitary | ECE2011

Effects of short (6 months) and long (18 months) term treatment with GH-receptor antagonist pegvisomant (PEG) on rhythm disturbances in acromegaly

Auriemma Renata Simona , Pivonello Rosario , De Martino Maria Cristina , Cudemo Giuseppe , Galdiero Mariano , Grasso Ludovica F S , Simeoli Chiara , Colao Annamaria

Aim: To evaluate the effects of short and long-term treatment with PEG on rhythm disturbances in a cohort of acromegalic patients resistant to long-term high-dose therapy with SA.Patients and methods: Thirteen patients (4 M, 9 F, aged 44±9.25 years) entered the study. All patients started PEG at initial dose of 10 mg daily, then increased of 5 mg every 6 weeks on the basis of IGF1 levels, until IGF1 normalisation or until the achievement of the maxi...

ea0020p196 | Endocrine tumours and neoplasia | ECE2009

Safety of long-term combined therapy with somatostatin analogues and cabergoline (CAB) on cardiac valve in acromegaly: an echocardiography study

Auriemma Renata Simona , Galderisi Maurizio , Galdiero Mariano , Grasso Ludovica Francesca Stella , De Martino Maria Cristina , De Leo Monica , Colao Annamaria , Pivonello Rosario

The aim of the present study was to evaluate cardiac valve insufficiency prevalence after 12-month combined treatment with somatostatin analogues (SA) and CAB in acromegalic patients partially responsive to high-dose and long-term SA monotherapy. Twenty-four patients entered the study. A standard echocardiography was performed in all patients at diagnosis, after high-dose and long-term SA therapy and 12 months after CAB addition to SA to evaluate ejection fraction (EF) and mit...

ea0016oc1.5 | Neuroendocrinology and pituitary | ECE2008

Cardiac performance after long-term treatment with Pegvisomant in patients with acromegaly: a radionuclide angiography study

Auriemma Renata Simona , De Martino Maria Cristina , Galdiero Mariano , Acampa Wanda , De Leo Monica , Lombardi Gaetano , Cuocolo Alberto , Colao Annamaria , Pivonello Rosario

GH and IGF-I excess causes a specific cardiomyopathy, often complicated by diastolic and systolic dysfunction until heart failure. The aim of this study is to evaluate the effects of long-term treatment with pegvisomant on cardiac performance in acromegalic patients. Twelve patients (4 men and 8 women, age 29–58 years) entered the study. A radionuclide angiography at rest and during exercise was performed at baseline and after 18 months of treatment with pegvisomant with ...

ea0016p4 | Adrenal | ECE2008

Might the response of cortisol to oral glucose tolerance test be used for the differential diagnosis of Cushing's syndrome and pseudo-Cushing's states?

De Martino Maria Cristina , De Leo Monica , Ochoa Arantzazu Sebastian , Auriemma Renata Simona , Galdiero Mariano , Lombardi Gaetano , Colao Annamaria , Pivonello Rosario

The pseudo-Cushing states (PCS) include several clinical conditions such as obesity, polycystic ovary syndrome, depression and alcoholism, characterized by physical features and abnormalities of hypothalamus–pituitary–adrenal axis similar to Cushing’s syndrome (CS). The differential diagnosis between CS and PCS is often complicated and requires several hormonal tests. The aim of this study is to evaluate the diagnostic accuracy of the cortisol response to the or...