Searchable abstracts of presentations at key conferences in endocrinology

ea0016pl3 | The red wine hypothesis: resveratrol and human metabolism | ECE2008

A cofactor network that controls PGC-1α activity and energy homeostasis

Auwerx Johan

Dysfunctional mitochondrial oxidative phosphorylation and diminished aerobic capacity are associated with metabolic, cardiovascular and neurodegenerative diseases that eventually alter life span. We will discuss two distinct signalling pathways to control energy expenditure that converge on the coactivator PGC-1α. In a first study we focussed on the polyphenol resveratrol, an activator of the class III HDAC SIRT1, the mammalian Sir2 homolog. Resveratrol significantly incr...

ea0016p158 | Clinical cases | ECE2008

Does cyproterone acetate promote multiple meningiomas?

Froelich Sebastien , Dali-Youcef Nassim , Boyer Patrick , Kehrli Pierre , Maitrot Daniel , Auwerx Johan , Schlienger Jean-Louis

Multiple meningiomas are rare benign tumors (1.5% of all meningiomas). They are either sporadic or associated with neurofibromatosis. Their long term morbidity is high due to the frequency of surgical procedures needed to overcome the absence of efficient adjuvant therapy. We present a cohort of patients in whom we strongly suspect cyproterone acetate to be responsible for the development and progression of multiple meningiomas.Patients and methods: We r...