Endocrine Abstracts

Background: Juvenile onset type 1 diabetes (T1D) is one of the most common chronic diseases in childhood and shows a rising incidence over the past decades. The exact pathogenesis is still not completely understood, especially regarding possible environmental factors triggering disease onset.Aim: We aimed to systematically review literature on growth in children prior to diagnosis of juvenile type 1 diabetes and to ascertain whether specific patterns of ...

A patient, female, 53 years old was admitted for investigation and treatment of active acromegaly. At the age of 33 on the basis of the clinico-hormonal and CT investigations was diagnosed mixed pituitary adenoma - somatoprolactinoma. GH was 15.4 ng/ml (0–10 in healthy), prolactin (prl) 2000 ng/ml (<580 in healthy). The short course of parlodel therapy had no effect. At the age of 40, she was performed with transsphenoidal adenomectomy. Afterwards, diabetes mellitus (...

Background and aims: Earlier we reported, that GADA and ICA revealed more often in HBV and HCV infected type 2 diabetic patients, than in noninfected. The goal was to determine the role of HBV- and HCV-infections in insulin insufficiency mechanisms in type 2 diabetic patients.Materials and methods: 173 patients with type 2 DM (41 male, 132 female, middle age 57.5±0.8 year, average diabetes duration 8.55±0.53 years) were surveyed. Markers of a v...

Background and aims: High prevalence of diabetes mellitus (DM) in patients with viral hepatites is observed. Trigger role of HBV and HCV infection in development of autoimmune reactions in diabetic patients is discussed. The goal was to study influence of hepatotropic viruses (HBV and HCV) on development of autoimmune processes to pancreatic β-cells.Materials and methods: patients with type 2 DM (41 male, 132 female, middle age 57.5±0.8 year, a...

Material and methods: Data for 124 554 DM patients is contained in the DM register of Moscow region (MR) for 2004. Mortality is evaluated yearly.Results: Mortality as result of T1D was 1.92, and of T2D – 41.82 people for 100 thousand population. Mortality among men surpasses mortality among women for T1D (2.11 men/1.76 women), whereas the opposite was observed for T2D (58.79 women/21.81 men). Life expectancy after a diagnosis of sugar diabetes is ma...

Background and aims: Diabetic foot ulcers are a common problem and result in lower extremity amputations. Research on the prevalence of diabetic foot syndrome (DFS), food ulcers, and high amputations reflects the state of diabetic aid.Materials and methods: The data from the Moscow Region DM register on the detectability of DFS, the number of high amputations, the presence of late complications that enable the development of ulcer defects – diabetic...

Background: Diabetic nephropathy is leading cause of end-stage renal disease (ESRD), which requires dialysis or a transplant. Progression of diabetic nephropathy (DN) leads to development of chronic renal failure (CRF).Material and methods: Data for 124 554 DM patients who live in Moscow region (MR) is in the MR DM register for 2004. The number of T1D- 8747, T2D patients is 115, 534. These registers only contain information about registered cases of DN.<...

The benign prostatic hyperplasia (BPH) represents an enlargement of the epithelial and fibromuscular parts of the prostate. Although androgens per se do not cause BPH, an intact androgen metabolism is a prerequisite for the normal fetal and pubertal development of the prostate. Furthermore, growth factors play a role in the development of BPH. Animal experiments have shown that the prostate – similar to other organs of the reproductive tract – undergoes a neonatal st...

Male- or female-like neural control of gonadal function and reproductive behaviour is determined by sex-specific activation of estrogen receptors (ER) in the developing brain during a limited, critical period during ontogenesis. Exposure of the neonatal female brain to inappropriately high estrogen concentrations results in irreversible defeminization of neuroendocrine function which is manifested by disturbed cyclic ovarian activity and decreased female sexual receptivity in ...

The suppression of serum TSH is a marker for increased risk of vascular mortality or death due to other causes are unknown. Nevertheless, patients who was operated on account of differentiated carcinoma of thyroid, had to take high doses of thyroxine for a long time to achieve suppression of TSH<0.1 mU/l. Heart rate variability (HRV), a method of mathematical analysis of heart rhythm (computer analysis of 24 h Holter monitoring), was used to assess function of the autonomi...