Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1379 | Thyroid (non-cancer) | ECE2017

Effects of combination of metformin and pioglitazone on AMPK/mTOR signal pathway, p53 and apoptosis in human anaplastic thyroid cancer cells

Kutbay Nilufer Ozdemir , Erdogan Mehmet , Yurekli Banu Sarer , Kurt Cansu Caliskan , Gunduz Cumhur , Avci Cigir Biray

Thyroid cancer is the most common malignant tumor of the human endocrine system. Recently, its incidence has increased significantly. Anaplastic cancer constitutes 2–4% of thyroid cancers and remains aggressive. The life expectancy is 2–6 months. It is often beyond the surgical margin. External radiation therapy or chemotherapy are the treatment options. Therefore, new therapeutic approaches are needed. Peroxisome proliferator-activated receptor (PPAR) gamma is a DNA...

ea0035p1107 | Thyroid Cancer | ECE2014

Effects of zoledronic acid monohydrate on cytotoxicity and apoptosis in BCPAP human papillary thyroid carcinoma cell line

Simsir Ilgin Yildirim , Kocabas Gokcen Unal , Yurekli Banu Pinar Sarer , Avci Cigir Biray , Saygili Lutfiye Fusun

Thyroid cancer in Turkey is the most common endocrine neoplasm with an incidence of 3.7%. Papillary thyroid carcinoma is the most common thyroid malignancy in a similar manner. Papillary thyroid carcinoma creates 50–90% of differentiated thyroid carcinomas. There is available in subgroups with poor prognosis. Case-specific mortality of 2% at 5, 10, and 20 years, only 4 and 5%.Mutations and re-arrangements in genes encoding proteins of the MAPK pathw...

ea0035p1093 | Thyroid Cancer | ECE2014

Atorvastatin medullar thyroid cancer over TT cell line impact of apoptosis and calcitonin over gene expression

Baykan Emine Kartal , Avci Cigir Biray , Erdogan Mehmet , Cetinkalp Sevki , Ozgen A Gokhan , Gunduz Cumhur , Saygili L Fusun

Medullar thyroid cancer (MTK) approximately constitutes 5% of thyroid cancer, over the 25% cases it progresses in familial form. In charge of genetic inherited clinical features in RET protooncogene ‘germ-line’ makes up activating mutations. In post RET mutation in association with tyrosine kinase activation oncogenic cell proliferation is increased. In medullary thyroid cancer persistent and recurrence disease management is complicated, because it is unresponsive to...

ea0032p484 | Diabetes | ECE2013

Copeptin: may it be a novel biomarker for insulin theraphy in subjects with diabetes?

Harman Ece , Dodurga Yavuz , Gundogdu Gulsah , Ayada Ceylan , Erken Gulten , Kucukatay Vural , Avci Cigir Biray , Genc Osman

Background and aim: As a prognostic marker, copeptin levels were independent predictors of survival in critically ill patients suffering from hemorrhagic and septic shock. Copeptin levels also have prognostic implications in chronic diseases other than acute illness. The stress-mediated activation of the HPA axis may be have role in the pathogenesis of the insulin resistance, metabolic syndrome, and diabetes. Furthermore, AVP action has been linked to liver glycogenolysis and ...