Endocrine Abstracts

Introduction: Surgical treatment is indicated in patients with dopamine agonist-resistant macroprolactinoma. However, the resection of the tumor is usually partial because of fibrotic changes under long-term dopamine agonist therapy. Thus, early identification and management of patients at high risk of dopamine agonist resistance is crucial to a complete resection outcome and a better remission. The aim of this study was to develop a score predicting dopamine agonist resistanc...

Recurrent hypoglycemia is a major clinical problem. In fact, it disrupts blood glucose regulation and greatly impacts the daily lives of those affected. Maintaining glycemic balance is a real challenge indiabetic patients. The objectives of the study were to determine the prevalence of hypoglycemia in type 2 diabetics and to evaluate their knowledge.Patients and methods: This was a cross-sectional study conducted among 120 type 2 diabetic patients follow...

Introduction: Giant pituitary adenomas are defined as tumors with largest diameter ≥40 mm. They are characterized by high invasiveness causing compression of adjacent structures and hormonal dysfunction. The aim of this study was to determine the clinical and paraclinical features, management, and outcome of giant pituitary adenomas.Methods: This was a single-center retrospective study including patients with giant pituitary adenoma. Clinical and p...

IntroductionEmphysematous pyelonephritis (EPN) is a necrotizing infection of the renal parenchyma which occurs preferentially in diabetics and is fraught with heavy mortality. Adequate therapeutic management is controversial: medical or surgical, conservative or radical. We report two observations of emphysematous pyelonephritis in two female diabetic patients, aged 58 and 50 years old, respectively.Observation<p class="abstext...

IntroductionPremature ovarian insufficiency (POI) is characterized by the loss of ovarian activity before the age of 40. It is associated with hypoestrogenism, raised gonadotrophins and oligomenorrhea or amenorrhea. POI is a heterogeneous disease that can result from different etiologies, including genetic, autoimmune, and iatrogenic. Of the genetic causes, single-gene mutations and chromosomal imbalances involving X chromosome or autosomes have been ass...

IntroductionGraves ophthalmopathy (GO) is an inflammatory autoimmune disorder of the orbit which is associated with autoimmune thyroid disease. The medical treatment of severe and sight threatening GO remains a challenge, it generally implies the use of glucocorticoids with others treatments. Mycophenolate mofetil (MMF) is a prodrug of mycophenolic acid that prevents T-cell and B-cell proliferation and the production of cytotoxic T-cells and antibodies. ...

IntroductionPrimary adrenal lymphoma (PAL) are rare extranodal lymphomas and account for<1% of all non-Hodgkin lymphomas, with characteristic clinical features including high incidence of bilateral involvement, predominantly diffuse large B-cell histology, and low incidence of extra-adrenal disease at diagnosis. We report a case of 50-year-old patient affected by bilateral B-cell adrenal lymphoma.Case presentation<p class="...

Patients with polycystic ovary syndrome (PCOS) have features of the metabolic syndrome, including insulin resistance, obesity, and dyslipidemia, suggesting an increased risk for cardiovascular disease.ObjectiveTo assess the prevalence of metabolic syndrome in patients with a polycystic ovarian sydrome (PCOS).MaterialWe conducted a retrospective study including 51 patients with secondary...

Introduction: The insulin tolerance test (ITT) is the gold standard for hypothalamic–pituitary adrenal axis assessment. There are different protocols depending on the number and timing of serum samples. Our study aimed to investigate the kinetics of serum glucose and cortisol levels during ITT and to determine the most appropriate times for blood samples.Methods: Our study was cross-sectional and descriptive. One hundred patients with suspected adre...

Introduction: Carotid intima-media thickness (CIMT) is a simple and non-invasive method used to detect atherosclerosis. This measure could predict future cardiovascular events. Some studies have showed an increased cardiovascular in non functional adrenal incidentalomas (NFAI). The aim of this case control study was to determine the relationship between NFAI and CIMT.Methods: This case control study included 40 NFAI patients (16 men, 24 women, mean age 5...