Endocrine Abstracts

Introduction: Abnormal uterine bleeding (AUB) refers to uterine bleeding that is excessive or occurs outside of normal cyclic menstruation. The most common cause of AUB in adolescents is anovulatory cycles due to immature hypothalamic-pituitary-ovarian axis. Additionally, endocrinological problems (hypothyroidism, hyperprolacitenemia, etc.) and bleeding disorders may cause AUB. The management of AUB begins with an assessment of whether or not the patient is hemodynamically sta...

Objective: Obesity and vitamin D deficiency are become most important public health problems independently. We aimed to investigate the relationship between vitamin D levels and metabolic sydrome (MetS) in obese children and adolescents.Patients and methods: 51 obese children/adolescents at the age of 12.4±2.73 (7.0–18.0) years and 48 age–sex matched healthy controls were enrolled. Serum 25 OHD, 1,25 (OH)2 D, calcium, phosphorus, alkal...

Objective: To investigate the changes in serum creatine kinase (CK) levels during the treatment of patients with growth hormone (GH).Methods: We evaluated 715 cases who were treated with GH retrospectively. The clinical data of 20 children with severe CK elevation (>500 IU/L) were analyzed.Results: CK elevation was recorded in 96 of the cases (13.5%) during GH theraphy. 20 of these patients had severe CK elevation. The mean age...

Background: The presence of the Y chromosome and Y-specific sequences (e.g: SRY, DYZ1, DYZ3, DYS132, ZFY, and TSPY, etc) in Turner syndrome patients is a risk factor for gonadal tumors (mostly gonadoblastoma) in dysgenetic gonads. Unfortunately approximately 60% of gonadoblastoma cases, there is a potential to progress towards invasive germ cell tumors (mostly dysgerminoma). Girls with Y chromosomal material also present a higher risk of virilization...