Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep356 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Plasma omentin-1 level does not change in the first trimester in women with gestational diabetes mellitus

Sancak Seda , Aydin Hasan , Sargin Mehmet , Orcun Asuman , Ozdemir Ali , Celik Ayhan , Aslan Gulgun

Objective: Gestational diabetes mellitus (GDM) is strongly associated with maternal obesity. Omentin-1 is secreted from the adipose tissue and enhances insulin action. Circulating levels are inversely correlated with body weight, decreased in type 2 diabetes. Pre-existing maternal obesity has been shown to be associated with lower omentin-1 expression in placenta, adipose tissue and maternal plasma. In our previous study, we had shown that plasma omentin-1 level is decreased i...

ea0037ep358 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Serum irisin level increases throughout the gestational period and it does not play role in development of gestational diabetes mellitus

Seda Seda , Aydin Hasan , Sargin Mehmet , Orcun Asuman , Ozdemir Ali , Celik Ayhan , Aslan Gulgun

Objective: Irisin is a novel adipomyokine that regulates the differentiation and phenotype of adipose tissue. It induces an increase in total body energy expenditure, improves insulin sensitivity, and glucose tolerance. It showed that the levels of irisin are low in obese, diabetic and impaired glucose tolerance patients. However, the information of the levels of circulating irisin in gestational diabetes mellitus (GDM) is controversial. In this study, we investigated i) the l...

ea0014p406 | (1) | ECE2007

Carotid intima media thickness and bone turnover in type 2 diabetic patients

Sancak Seda , Yavuz Dilek , Toprak Ahmet , Deyneli Oguzhan , Tarcin Ozlem , Yazici Dilek , Aydin Hasan , Akalin Sema

Recent studies indicate that atherosclerotic process is associated with bone metabolism. The aim of this study was to evaluate carotid intima media thickness (CIMT) and its association with bone mineral density and bone turnover markers as well as inflammation markers in type 2 diabetic male patients.Material-method: 184 type 2 diabetic males (56±8 y) and 85 non-diabetic control subjects (52±7 y) were recruited. Bone mineral density was measure...

ea0014p337 | (1) | ECE2007

The relationship of epicardial fat thickness with carotid intima media thickness and endothelial function in subclinical and overt hypothyroidism

Yazici Dilek , Aydin Hasan , Özben Beste , Toprak Ahmet , Yavuz Dilek , Tarcin Ozlem , Sancak Seda , Deyneli Oguzhan , Akalin Sema

Hypothyroidism is associated with increased cardiovascular mortality. Epicardial fat thickness (EFT) has been found to be correlated with visceral fat accumulation and is thought to be a novel cardiovascular risk factor. The aim of this study was to determine EFT and its relationship with carotid intima media thickness (CIMT) and flow-mediated vasodilation (FMD) in subclinical and overt hypothyroid patients.Ten patients with overt (Group H) (42.2±15...

ea0049ep440 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Postpartum Tip 2 DM follow-up after gestational diabetes mellitus

Sancak Seda , Ozdemir Ali , Abacar Kerem Yiğit , Celik Ayhan , Okuroğlu Nalan , Sertbaş Yaşar , Aydin Hasan

Purpose: GDM is defined as any degree of carbonhydrate intolerance that is first diagnosed during pregnancy. Patients diagnosed with GDM are expected to have complications such as Type II DM, obesity, hypertension in the long term. Prevalence of GDM diagnosis during pregrancy changes between 2 and 10%. Our purpose is to revaluate the OGTT of the patients diagnosed with GDM, with regard to their postpartum Type II DM progress.Materials and methods: 450 pr...

ea0014p396 | (1) | ECE2007

Vitamin D receptor gene polymorphisms: influence on bone metabolism in type 1 diabetic patients

Yavuz Dilek Gogas , Yazici Dilek , Yüksel Meral , Kiyici Sinem , Sert Murat , Sahin Ibrahim , Keskin Lerzan , Deyneli Oguzhan , Aydin Hasan , Tuncel Ercan , Akalin Sema

Patients with type 1diabetes mellitus are at higher risk of developing osteoporosis. Among the genetic factors related to the development of osteoporosis, a possible association between vitamin D receptor (VDR) gene polymorphism and bone mineral density (BMD) has been described in some populations.The aim of this study is to investigate the distribution of vitamin D receptor (VDR) polymorphisms and relation to bone turnover parameters and bone densitomet...

ea0014p411 | (1) | ECE2007

Vitamin D receptor gene Bsm1 and Fok1 polymorphisms and indices of bone mass and bone turnover in healty young Turkish men and women

Yavuz Dilek Gogas , Yuksel Meral , Tarcin Ozlem , Yazici Dilek , Telli Ahu , Sancak Seda , Deyneli Oguzhan , Aydin Hasan , Haklar Goncagul , Akalin Sema

Aim: Peak bone mass is a major determinant of osteoporosis risk in later life. It is under strong genetic control; In the present study, we investigated the relationship between polymorphisms in the gene encoding the vitamin D receptor (VDR) (FokI and Bsm 1) and bone mineral density (BMD), bone mineral content (BMC), and markers of bone turnover in 106 young Turkish women (19–23 yrs) and 100 man (19–23 yrs). Methods: BMD and BMC were measured by dual-energy X-ray abs...

ea0056gp83 | Diabetes Epidemiology | ECE2018

Prevalence and predictors of gestational diabetes mellitus: a nationwide multicenter prospective study

Aydin Hasan , Celik Ozlem , Yazici Dilek , Altunok Cigdem , Tarcin Ozlem , Deyneli Oguzhan , Sancak Seda , Kiyici Sinem , Aydin Kadriye , Yildiz Bulent Okan

Aim: Gestational diabetes mellitus (GDM) is an important public health issue associated with significant short- and long-term morbidity both for mother and offspring. Prevalence rates of GDM show considerable variation among different countries and regions of the world. The primary aim of this study was to determine the nationwide prevalence and predictors of GDM in Turkey.Materials and methods: We conducted a prospective nationwide screening among pregn...