Endocrine Abstracts

Background: The 4th edition of World Health Organization (WHO) classification of pituitary tumors recommended evaluation of tumor proliferation and invasion to identify aggressiveness. We aimed to assess the relationship between Ki-67, mitotic index, P53 expression, invasion and recurrence risk in pituitary adenomas.Methods: Among 601 patients who underwent TN/TS adenomectomy between 2001 and 2016, 101 patients (16.8%) who had tumors with Ki-67 index &#8...

Due to inhibition affect on proliferation, motility, resistance to apoptosis and growth of metastasis, the epidermal growth factor receptor (EGFR) inhibitor erlotinib and vascular endothelial growth factor receptor (VEGF) and EGFR inhibitor vandetanib are viable treatment options for treatment of advanced non-small cell lung cancer and thyroid cancer respectively. Advanced non-small cell lung carcinomas (NSCLC) or medullary and differentiated thyroid carcinomas (MTC and DTC) m...

Background: Fahr’s disease is a rare degenerative disorder characterized by symmetrical and bilateral intracranial calcification. Movement disorders are the most common symptoms of Fahr’s disease and dystonia is an uncommon presentation which accounts for only 8% of symptomatic patients.Case report: A 47 years old female admitted to emergency department with involuntary movements of extremities and anxiety. Neurological examination was normal e...

Introduction: Werner’s Syndrome (WS) is a rare autosomal recessive adult onset progeroid disorder characterized by the early onset of aged-appearance and age related metabolic disorders. Patients usually develop normally until the 3rd decades of life.Case report: We report a 27 years old female who admitted to our clinic at the age of 15 with hyperglycemia. She was diagnosed as diabetes and type 4 dyslipidemia at the age of 7 years. In her family hi...

Introduction: It is known that patients with primary hyperparathyroidism (PHPT) have an increased cardiovascular morbidity and mortality. In our study, we aimed to investigate the cardiovascular risk factors in medically observed and operated PHPT patients.Materials and methods: Twenty-nine medically observed (group A), 25 pre-operative (group B) and 23 post-operative (group C) patients with PHPT and 26 normocalcemic patients as control group (group D) w...

Introduction: Disease control in acromegaly can be achieved by surgery, medical treatment, and radiotherapy either alone or in combination. The acromegaly patients whom tumour shrinkage cannot be provided or growth hormone levels do not decrease under multiple treatment modalities are designated as resistant acromegaly. We aimed in our study to evaluate the clinical features of resistant acromegaly patients and determine their responds to different treatment modalities.<p ...

Background: Recombinant human thyroid-stimulating hormone (rhTSH)-stimulated serum thyroglobulin (Tg) (s-Tg) and (131)I whole-body scanning (WBS) are supposed to provide equal diagnostic information with thyroxine withdrawal (THW) at follow-up thyroid cancer patients without the symptoms of hypothyroidism. We aimed to compare the WBS and s-Tg levels after thyrogen injection and thyroid hormone withdrawal for tumor recurrence/persistance according to the risk groups.<p clas...

Introduction: RET mutation analysis has a critical importance for determining clinical approach to hereditary medullary thyroid carcinoma (MTC). The current guidelines recommends to determine the timing of prophylactic thyroidectomy depending on the risk stratification, mainly decided by the type of the mutation.Methods: Society of Endocrinology and Metabolism of Turkey (SEMT) sponsored ret genetic screening between July 2008 and January 2012 in 513 pati...

Introduction: TURK-MEN study was carried out to evaluate the mutational analysis of so called sporadic MTC patients between 1994 and 2005. Our aim was to evaluate the ret genetic screening results, distribution of mutations among so called sporadic and hereditary MTC patients in Turkey between 2008 and 2012.Methods: Society of Endocrinology and Metabolism of Turkey (SEMT) sponsored ret genetic screening between July 2008 and January 2012 in 513 patients....