Endocrine Abstracts

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Graves’ disease is the most common cause of autoimmune hyperthyroidism in pregnancy accounting for 0.1 to 1% (0.4% clinical and 0.6% subclinical) of all pregnancies. It may be diagnosed for the first time in pregnancy, may present as a recurrent episode in a woman with past history of hyperthyroidism, or in a women on antithyroid drugs (ATD). Less common non autoimmune causes include multinodular goiter, toxic adenoma, and factitious hyperthyroidism. More frequent than Gr...

Changes in serum lipid and lipoprotein concentrations occur frequently in disorders of thyroid function. LDL-C oxidation susceptibility is higher in these patients than in normal population. This study aims at assessing lipids, lipoproteins, lipid oxidations and serum paraoxonase activity in patients with subclinical hyperthyroidism. Forty patients were compared with an age and sex matched control group. A fasting blood sample was obtained and serum total cholesterol, triglyce...

Introduction: Studies show that a change in lifestyle can prevent or delay progression to diabetes in those with glucose intolerance. This study aimed to survey the effects of lifestyle changes on incidents of type II diabetes in Tehran adult population.Materials and methods: This was a community based interventional study. Non-diabetic participants of Tehran Lipid and Glucose Study aged ≥20 years (6437 in control group and 2931 in intervention gro...

Introduction: It is evident that hypothyroid patients have higher BMI than euthyroids. Until recently, much attention has been focused on finding whether minor abnormalities of thyroid function or differences in thyroid status of euthyroid subjects are related to body weight. Controversies, however, exist regarding the role of TSH in weight changes of euthyroid subjects.Objective: The aim of this study, the Tehran Thyroid Study, was to determine any poss...

Patients with thyroid dysfunction are more susceptible to oxidative stress, and may show enhanced LDL-C oxidation. The purpose of this study was to evaluate serum paraoxonase activity and antioxidants in patients with endogenous subclinical hyperthyroidism.Forty-one subclinical hyperthyroid patients, 30 women and 11 men, aged 47±13 years, and 40 age and sex matched healthy controls were studied. Serum paraoxonase activity, lipid, lipoprotein, oxidiz...

Objective: Although body mass index (BMI) is commonly used to assess risk for cardiovascular disease (CVD), there is an obvious need for prospective studies of different ethnics to evaluate the predicting power of various obesity variables for CVD outcomes.Methods: The study population consisted of 1931 men aged ≥40 years free of CVD at baseline. After a median follow up of 7.6 years, 254 CVD events occurred. Demographic data were collected at base...

Objective: To determine risk factor pattern of the metabolic syndrome (MetS) and its association with serum nitric oxide metabolites (NOx) in children and adolescents.Subjects and methods: A cross-sectional study was carried out in 409 male and 442 female children and adolescents aged 4 to 19 years. The ethical committee of our institute approved the study. The MetS was defined according to modified ATPIII criteria and factor analysis was used...

Background: Ischemic stroke is a major complication of diabetes mellitus. This survey was design to detect asymptomatic intracranial stenosis and determine it’s risk factors in diabetic patients older than 50 years with hypertension by transcranial doppler sonography (TCD).Methods: Between June 2003 and December 2004 all diabetic patients older than 50 years with hypertension and no previous history of cerebrovascular problems, were selected. After ...

Introduction: The prevalence of non-communicable disorders such as metabolic syndrome (MetS) is high in developing countries. MetS is a disorder of energy utilisation and storage, diagnosed by a co-occurrence of three out of five of the following medical conditions: abdominal (central) obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and low HDL cholesterol levels. The present review aims to discover the genetic variant reported in a...