ea0020oc5.3 | Thyroid: Basic and Clinical | ECE2009
, Azzam Naiel
, Bar-Shalom Rinat
, Kraiem Zaki
Introduction: Thyrotropin (TSH) and the gonadotropins (FSH, LH, hCG) are a family of heterodimeric glycoprotein hormones composed of two noncovalently linked subunits, α and β. hTSH, heterodimer was converted to a biologically active single-peptide chain, by fusing the common α subunit to the carboxyl-terminal end of hTSHβ subunit in the absence (hTSHβα) or presence of a ~30 aminoacid carboxyl-terminal peptide fr...