Searchable abstracts of presentations at key conferences in endocrinology

ea0014p502 | (1) | ECE2007

Endocrine tumour registry – tools for endocrine epidemiology

Badiu Corin , Sava Sorin

Endocrine tumour registry is a web-based system which is divided in several categories of endocrine tumours: pituitary adenomas, thyroid cancer, parathyroid tumours, adrenal and other types.The program is intended to give epidemiological data concerning the prevalence of each type, age and sex distribution, therapy and basic results of it. The centres involved are the medical universities and expertise centres in Romania, centres in which there are enoug...

ea0049ep830 | Adrenal cortex (to include Cushing's) | ECE2017

The metabolic impact of ACTH-dependent versus ACTH-independent Cushing’s syndrome: a retrospective study of 99 patients

Ilie Mirela Diana , Badiu Corin

Introduction: Although the metabolic impact of Cushing’s syndrome and hypercortisolemia are well known, the metabolic impact of ACTH is less established.Objective: To identify differences in the glucidic, lipid and bone metabolism in ACTH-dependent versus ACTH-independent Cushing’s syndrome.Methods: Retrospective, cross-sectional study of 99 patients with Cushing’s syndrome (54 with ACTH-dependent Cushing’s synd...

ea0081ep576 | Endocrine-Related Cancer | ECE2022

Panhypopituitarism and diabetes insipidus due to metastatic breast cancer

Cuconu Diana , Stancu Cristina , Badiu Corin

We report the case of a 36 years old female, with personal history of breast cancer, treated with neoadjuvant chemotherapy, breast sectorectomy and then chemotherapy and radiation therapy 2 years ago. She was continuously monitored by her oncologist, disease free for over a year, with recent CT scan that showed no particular lessions suggestive for secondary disease. Meanwhile, she got pregnant and delivered at term a healthy baby. She was admitted 3 months postpartum with int...

ea0081ep1060 | Thyroid | ECE2022

Sorafenib for metastatic thyroid carcinoma

Cuconu Diana , Iulia Chiriac , Badiu Corin

Differentiated thyroid cancers include papillary, follicular carcinomas and are usually associated with a good prognosis. Up to 10% of patients develop metastatic lessions and radioiodine resistance. Tirosine kinase inhibitors (TKI) represent a strong therapeutic option for patients with advanced metastatic disease and radioiodine resistance. Sorafenib is the only TKI approved for the treatment of locally advanced or metastatic differentiated radioiodine resistant thyroid carc...

ea0063p53 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

A rare association of neuroendocrine tumor with adenocarcinoma of ampulla of vater: difficulties for diagnosis and effects of multi therapeutic approach

Stanca Oana Stefania , Olariu Cristina , Badiu Corin

Introduction: The neuroendocrine tumor of the ampulla of Vater represent a very rare disease, corresponding up to 2% of the periampullary malignancies and less than 1% of gastrointestinal NET. Less than 130 patients have been reported until 2013. The biological and clinical behavior is very unpredictable especially if it’s associated with another tumor, like adenocarcinoma. We present a case of a fifty-one-years-old woman who complained of weight loss, jaundice, abdominal...

ea0063p881 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Epidemiology and evolution data on gastroenteropancretic and pulmonary neuroendocrine tumors

Olariu Cristina , Mirela Gherghe , Badiu Corin

Neuroendocrine tumors (NETs) includes a broad family of tumors, the most frequent ones are in the gastrointestinal tract, lung, thymus, and pancreas. Gas-trointestinal and Pulmonary NETs may present with symptoms attributable to hormonal hypersecretion, which include intermit-tent flushing and diarrhea, or symptoms related to Cushing Syndrome. The variability of clinical manifestation may lead to late referral or misdiagnosis. In this retrospective study we analyzed 27 patient...

ea0063p1114 | Pituitary and Neuroendocrinology 3 | ECE2019

Evolution of patients with discordance between growth hormone and insulin-like growth factor-1 after pituitary surgery for acromegaly

Olariu Cristina , Bojoga Andreea , Badiu Corin

Introduction: Persistent or intermittent postoperative discordance between growth hormone (GH) after OGTT and insulin-like growth factor-1 adjusted for age and gender (IGF-1) is up to 39% according to different studies. The aim of this study was to evaluate the impact of this discrepancy (normal GH and elevated IGF1 or vice versa) over the risk of biochemical and tumour recurrence after initial successful surgery for acromegaly.Methods: In this retrospec...

ea0049ep108 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Stress cardiomyopathy in pheochromocytoma

Gheorghiu Cristina Alexandra , Jercalau Simona , Badiu Corin

Introduction: Rare cases of pheochromocytoma are associated with stress induced Takotsubo cardiomyopathy explained by high catecholamine exposure causing microvascular spasm and direct myocardial impact.Case report: A 49-year-old female with a history of poorly controlled hypertension, with paroxysmal elevations in blood pressure and rare supraventricular extrasystoles, lipothymic events, was firstly assessed in the cardiologic department. She presented ...

ea0038p485 | Thyroid | SFEBES2015

Inadequate TSH – resistance to thyroid hormones: two case reports

Gogoi Adriana , Jercalau Simona , Badiu Corin

Resistance to thyroid hormones (RTH) is a genetic syndrome characterized by reduced responsiveness of target tissues to thyroid hormones (TH) and accompanied by normal or slightly high TSH values with high serum concentrations of fT4 or fT3. We present two cases of RTH, one pituitary and one generalised resistance.Case 1: A 31 y.o. male presented with thyrotoxicosis symptoms and a biochemical profile showing increased serum fT4...

ea0035p1132 | Thyroid Cancer | ECE2014

Treatment outcomes and prognosis of medullary thyroid carcinoma in a tertiary endocrinology center

Dobrescu Ruxandra , Stanescu Bogdan , Badiu Corin

A rare and aggressive form of thyroid malignancy, medullary thyroid carcinoma (MTC) is virtually incurable except by complete surgical resection. Due to its insidious onset and extensive spread at diagnosis, its prognosis is often poor.Aim: To evaluate treatment outcome and prognosis in patients diagnosed with MTC admitted to our department between 2004 and 2013.Patients and methods: We identified 21 patients (eight men and 13 wome...