Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1391 | Thyroid (non-cancer) | ECE2017

The impact of age and gender on the presentation and prognosis of medullary thyroid cancer – an Israeli multicenter study

Twito Orit , Grozinsky-Glasberg Simona , Benbassat Carlos , Llevy Sigal , Bachar Gideon , Gross David J , Hirsch Dania

Background: Data regarding the effect of gender and age on medullary thyroid cancer (MTC) presentation and prognosis is limited. Although older age and male sex were found to correlate with poorer prognosis in some studies, this correlation may reflect differences in MTC presentation between sex and age groups, or a mixture of hereditary and sporadic MTC forms.Objective: To evaluate the impact of age and sex on the presentation and outcomes of MTC.<p...

ea0049ep1374 | Thyroid (non-cancer) | ECE2017

Trends in the clinicopathological features and clinical outcomes of medullary thyroid carcinoma – an Israeli multicenter study

Hirsch Dania , Twito Orit , Levy Sigal , Bachar Gideon , Robenshtok Eyal , Gross David J , Mazeh Haggi , Benbassat Carlos

Background: The massive use of neck sonography has led to a dramatic increase in the incidence of thyroid cancer detection, predominantly small papillary carcinomas. However, changes in the presentation and course of medullary thyroid carcinoma (MTC) over time remain unclear.Objective: To evaluate trends in the presentation and outcomes of MTC.Methods: Patients treated for MTC at four medical centers in Israel were divided into two...

ea0081oc6.4 | Oral Communications 6: Endocrine-Related Cancer | ECE2022

Clinical correlates of a large Israeli cohort of Cys 618 Arg RET mutation

Chava Rosenblum Rachel , Hirsch Dania , Glasberg Simona , Benbassat Carlos , Yoel Uri , Ishay Avraham , Lamprecht Sagit Zolotov , Bachar Gideon , Banne Ehud , Twito Orit

Introduction: A syndrome of MEN2A and HirschsprungÂ’s disease described in Israeli Jews of Moroccan descent is caused by Cys 618 Arg mutation, one of the less common causes of MEN2A. We aimed to define the clinical characteristics of a large cohort with this mutation from a multi-center Israeli registry.Methods: The Israeli MTC registry including 8 centers was searched retrospectively for results of RET mutational analysis. Patients with a Cys 618 Ar...