ea0011p681 | Reproduction | ECE2006
Dhillo WS
, Chaudhri OB
, Patterson M
, Thompson EL
, Murphy KG
, Badman MK
, McGowan BM
, Amber V
, Patel S
, Ghatei MA
, Bloom SR
Mutation of the GPR54 receptor is associated with a failure of reproductive function. The endogenous neuropeptide agonist for GPR54, kisspeptin, potently stimulates the hypothalamic-pituitary-gonadal (HPG) axis in rodents and primates.Objective: The present study was designed to determine the effects of elevating circulating kisspeptin levels on LH, FSH and testosterone in male volunteers.Method: Study (i) Volunteers were infused w...