Searchable abstracts of presentations at key conferences in endocrinology

ea0016p363 | Growth factors | ECE2008

Does administration of octreotide acetate prevent development of diabetic nephropathy? an ultrastructural evaluation of the effects of octreotide acetate on kidney tisssue in Streptozotocin induced diabetic rats

Bahceci Selen , Nergiz Yusuf , Bahceci Mithat , Akkus Murat

Background and aims: Growth hormone and insulin-like growth factors to be involved in the pathogenesis of diabetic kidney disease. The aim of this study was ultrastructural evaluation of octreotide acetate on kidney tissue in streptozotocin (STZ) induced diabetic rats.Material and methods: Twenty-four male Spraque–Dawley rats divided into 3 groups; control (C), diabetic (D) and diabetic with octreotide aceatate (DO). The all diabetic rats were treat...

ea0014p238 | (1) | ECE2007

The association of high sensitivity C-reactive protein levels with body fat mass and body fat distribution

Gokalp Deniz , Tuzcu Alpaslan , Akay Hatice , Arikan Senay , Bahceci Mithat

Background and aim: C-reactive protein (CRP) is a sensitive marker for systemic inflammation. In this study we aimed to investigate the relationship between high-sensitivity C-reactive protein (hs-CRP) levels and BMI, body fat mass and fat distribution in healthy subjects.Subjects and methods: A total 117 healthy subjects aged with 20–68 yr [normal weight (BMI 18.5–25.0 kg/m2, n:35), overweight (BMI: 25–30 kg/m2</sup...

ea0014p271 | (1) | ECE2007

The relationship between carotid intima-media thickness metabolic and anthropometric parameters in healthy subjects

Akay Hatice , Gokalp Deniz , Arikan Senay , Tuzcu Alpaslan , Bahceci Mithat

Background and aim: Carotid intima-media thickness (IMT), as assessed by B-mode ultrasound, is a commonly used clinical marker that reflects systemic burden of atherosclerosis and value of IMT at or above 1 mm at any age is associated with a significantly increased risk of myocardial infarction. On the basis of such findings, we aimed to clarify the relationship between carotid intima-media thickness and anthropometric and metabolic parameters in virtually healthy subjects.</p...

ea0014p299 | (1) | ECE2007

Serum n-terminal pro-b-type natriuretic peptide (NT-proBNP) levels in patients with hyper- and hypothyroidism. Hyperthyroidism may affect NT-proBNP levels as independent of cardiac dysfunction

Arikan Senay , Tuzcu Alpaslan , Gokalp Deniz , Bahceci Mithat , Danis Ramazan

Background and aim: It was known that NT-proBNP levels increased in cardiac failure. But, NT-proBNP levels in different thyroid status still unclear. We aimed to evaluate serum NT-proBNP levels in both of hyperthyroid and hypothyroid patients without cardiac insufficiency.Subjects and methods: Thirty nine patients with hyperthyroidism (43.0±16.5 yr), 25 patients with hypothyroidism (35.4±13.9 yr) and 34 ages matched euthyroid subjects (41.4&#17...

ea0014p489 | (1) | ECE2007

GH-secreting adenomas may disappear with long-acting somatostatin analoque (octreotide-LAR) treatment

Arikan Senay , Gokalp Deniz , Tuzcu Alpaslan , Bahceci Mithat , Akay Hatice

Background and aim: Somatostatin analogues such as octreotide acetate were used in acromegalic patients as primary or secondary treatment. In this study we aimed to report completely disappearing of adenoma and clinical cure in 3 acromegalic cases that rejected surgical treatment.Case1: E.A (62 years old, female) She reported enlargement of his hands, deepening of his voice and increases in shoe size. MRI revealed a macro adenoma which was spread to cave...

ea0014p555 | (1) | ECE2007

Evaluation of insulin sensitivity with euglycemic hyperinsulinemic clamp technique in non-obese patients with microprolactinoma

Tuzcu Alpaslan , Yalaki Serkan , Arikan Senay , Gokalp Deniz , Bahceci Mithat

Background and aim: Hyperprolactinemia may associate with insulin resistance. This fact has been determined by many studies with methods which show insulin sensitivity. In this study we aimed to search insulin resistance with golden standard euglycemic hyperinsulinemic clamp technique on hyperprolactinemic patients.Subjects and methods: This study was performed in Endocrinology Department of Dicle University. Sixteen patients with microprolactinoma (mean...

ea0049ep937 | Pituitary - Clinical | ECE2017

Four decades without diagnosis: Sheehan‘s syndrome, a retrospective analysis

Gokalp Deniz , Alpagat Gulistan , Tuzcu Alpaslan Kemal , Bahceci Mithat , Tuzcu Sadiye , Yakut Fatime , Yildirim Azat

Aim: Sheehan‘s syndrome (SS) remains a frequent cause of hypopituitarism in undeveloped and developing countries, but due to improvements in obstetric care, it is rare in developed countries. We aimed to share the results of a retrospective study analyzing the demographic, clinical, imaging, and hormonal characteristics of a large group of patients with SS, and also increase awareness of this syndrome especially in developed countries.Methods: The m...

ea0014p394 | (1) | ECE2007

Increased cortisol level in type 1 diabetic patient may lead decreasing of bone mineral density

Tuzcu Alpaslan , Bayer Semir , Arikan Senay , Gokalp Deniz , Bahceci Mithat , Canoruc Naime

Objective: In this study we aim to investigate the association of osteoporosis and type 1 diabetes in 43 type 1 diabetic subjects and 41 control subjects.Subjects and methods: Bone mineral density of both groups was measured by DEXA. Age, BMI, waist/hip ratio, daily calcium consumption of both groups were determined. Twenty-four hours urinary calcium, phosphorus, deoxipyridinoline and pyridinoline were measured. Osteocalcin ALP, IGF-1, IBF-BP3. HbA1c, co...

ea0014p613 | (1) | ECE2007

Effect of hormone replacement therapy apart from growth hormone on the endothelial functions in patients with Sheehan’s syndrome

Bahceci Mithat , Pasa Semir , Akay Hatice O , Tuzcu Alpaslan , Arikan Senay , Gokalp Deniz

Aim: To examine the endothelial functions of patients with Sheehan syndrome (SS) and to eveluate the effects of hormone replacement treatment except growth hormone on endothelial functions.Subjects and methods: Twenty-four patients with Sheehan syndrome (PSS) aged 40.83±6.43 yr and 25 healthy control women aged 41.13±6.51 yr (C) were included. Endothelial functions were evaluated with high resolution ultrasonography (flow mediated dilatation:FM...

ea0016p13 | Adrenal | ECE2008

The prevalence of non-classic adrenal hyperplasia among Tturkish women with hirsutism

Unluhizarci Kursad , Kula Mustafa , Dundar Munis , Tanriverdi Fatih , Israel Shoshana , Colak Ramis , Dokmetas Hatice S , Atmaca Hulusi , Bahceci Mithat , Balci M Kemal , Comlekci Abdurrahman , Akarsu Ersin , Bilen Habip , Erem Cihangir , Kelestimur Fahrettin

Context: The prevalence of NCAH among Turkish women with hirsutism has not been established so far.Objective: To evaluate the prevalences of 21-hydroxylase (21-OHD) and 11-β hydroxylase deficiencies by ACTH stimulation test among hirsute women.Patients and methods: The study population consisted of 285 premenopousal women, aged 16–46 years (mean: 23.2±0.3). All were hirsute and hyperandrogenic. Androgen secreting tum...