Searchable abstracts of presentations at key conferences in endocrinology

ea0035oc6.4 | Bone, calcium & vitamin D | ECE2014

The REPEAT Study: An open-label clinical trial evaluating the safety and efficacy of recombinant human parathyroid hormone, rhPTH(1–84), for the treatment of hypoparathyroidism in hungary

Lakatos Peter , Bajnok Laszlo , Lagast Hjalmar , Valkusz Zsuzsanna

In hypoparathyroidism, inadequate levels of parathyroid hormone (PTH) result in hypocalcemia and often hyperphosphatemia. Large doses of calcium (Ca) and active vitamin D are typically used to manage symptoms, although these are often associated with complications and do not address the underlying PTH deficiency. In the phase III REPLACE trial, 24 weeks of treatment with rhPTH(1–84) was associated with maintained serum Ca without urine Ca excretion increases despite clini...

ea0037ep733 | Pituitary: clinical | ECE2015

Evaluation of GH secretion after stroke

Nemes Orsolya , Tarjanyi Zita , Szapary Laszlo , Ruzsa Beata , Bodis Beata , Bajnok Laszlo , Mezosi Emese

Objective: According to recent studies, impaired secretion of GH is a frequent finding after ischaemic stroke. The aim of our study was to compare various available GH stimulation tests in post-stroke patients.Design: Seventeen patients were included in the study (12 males; mean age: 60.5 years; mean BMI, 27.7 kg/m2) with a mean 19.6 (±7.3) months after stroke. For screening, glucagon and small dose (0.15 μg/kg) GHRH-arginine (sdGHRH...

ea0032p1097 | Thyroid cancer | ECE2013

The role of radioiodine SPECT/CT in differentiated thyroid cancer

Mezosi Emese , Bajnok Laszlo , Rucz Karoly , Weninger Csaba , Schmidt Erzsebet , Szabo Zsuzsanna , Szekeres Sarolta , Zambo Katalin

Introduction: Beside remnant ablation and treatment of known metastases, radioiodine treatment of differentiated thyroid cancer is suitable for the discovery of unknown or suspected metastatic disease. In this study, the clinical utility of SPECT/CT, a hybrid imaging method was evaluated after radioiodine therapy.Patients and methods: Between July 2007 and March 2012, 260 investigations were performed at 188 patients. Male:female ratio was 47:141. Every ...

ea0014p472 | (1) | ECE2007

Relapse of hyperthyroidism in Graves’ disease after long-term drug treatment

Mezosi Emese , Nemes Orsolya , Bodis Beata , Nagy Zsuzsanna , Ruzsa Beata , Rucz Karoly , Bajnok Laszlo

The optimal treatment of hyperthyroidism in Graves’ disease is still an unresolved question. Hyperthyroidism recurs in 50% of patients after discontinuation of antithyroid therapy. In this retrospective study, Graves’ patients investigated in the endocrine unit of Pecs University between December 2004 and October 2006 were enrolled (68 women, 22 men, age 47 (15–79) years). Antithyroid drug therapy was applied for a minimum of one year and the treatment was withd...

ea0063gp73 | Thyroid Autoimmune Disorders | ECE2019

Clinical experiences in autoimmune polyglandular diseases

Pham-Dobor Greta , Bajnok Laszlo , Bodis Beata , Gergics Marin , Nemes Orsolya , Rucz Karoly , Mezősi Emese

Introduction: The autoimmune polyglandular syndrome is a complex, heterogeneous disease in which autoimmune diseases of endocrine and non-endocrine organs can occur. There are 4 subgroups: the early-onset APS I develops due to the mutation of the gene AIRE and characterized by the presence of Addison’s disease (AD), mucocutan candidiasis and hypoparathyroidism; the APS II is defined by the appearance of AD and autoimmune thyroid diseases (AITDs) and/or diabetes mellitus; ...

ea0063gp169 | Obesity (1) | ECE2019

The role of copeptin and cortisol in critically ill patients

Gergics Marin , Pham-Dobor Greta , Tarjanyi Zita , Montsko Gergely , Kőszegi Tamas , Mezősi Emese , Bajnok Laszlo

Introduction: Both cortisol and vasopressin are stress hormones. Earlier, our group demonstrated that serum concentrations of free cortisol at admissions to the Intensive Care Unit (ICU) were independent predictors of survival in critically ill patients. Other investigators have demonstrated that serum copeptin, a surrogate marker of vasopressin may also be a predictive factor in this patient population. The aim of our present study was to compare the prognostic roles of serum...

ea0063p756 | Thyroid 2 | ECE2019

Systematic review and meta-analysis of occurrence of other autoimmune diseases in autoimmune polyglandular syndrome type II and type III

Pham-Dobor Greta , Bajnok Laszlo , Gergics Marin , Hanak Lilla , Hegyi Peter , Marta Katalin , Mezősi Emese

Introduction: The autoimmune polyglandular syndrome (APS) is a complex, heterogeneous condition in which autoimmune diseases (AIs) of endocrine and non-endocrine organs can occur. There are four subgroups. The majority of patients are categorized as having APS II or APS III. In APS II, patients have Addison’s disease (AD) and autoimmune thyroid diseases (AITDs) or type I. diabetes mellitus (T1DM), while in the APS III, AITDs are combined with other autoimmune illnesses ex...

ea0014p135 | (1) | ECE2007

Papillary thyroid cancer – the possible role of death ligands in tumor immunology

Mezosi Emese , Gyory Ferenc , Borbely Agnes , Ujhelyi Bernadett , Soos Gyorgyike , Nagy Endre V. , Varga Zsuzsa , Bajnok Laszlo

Papillary thyroid cancer (PTC) cells and immune cells can kill each other by death ligands. Death ligands induce apoptosis only in sensitive cells. The sensitivity to apoptosis is regulated in a complex and poorly understood manner. The aim of this study was to investigate the Fas ligand (FasL) and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) expression in PTC cells and tumor infiltrating immune cells. Twenty-six PTCs without and fifteen PTCs with cervical l...

ea0014p479 | (1) | ECE2007

Pituitary insufficiency after traumatic brain injury in southwest Hungary

Nemes Orsolya , Nagy Zsuzsanna , Bodis Beata , Bajnok Laszlo , Szellar Dora , Czeiter Endre , Buki Andras , Doczi Tamas , Mezosi Emese

Traumatic brain injury (TBI) often results in long-term pituitary insufficiency. Regular endocrine screening of TBI patients is advised after the acute phase of the treatment period. We monitored pituitary functions in 32 TBI patients (28 men, 4 women). Endocrine tests were performed from 3 to 36 months after the brain injury. Thyroid functions, cortisol and ACTH levels, prolactin, sex hormone concentrations, GH/IGF1 axis and posterior pituitary function were evaluated. Additi...

ea0070aep974 | Thyroid | ECE2020

Humoral changes during resolution of short term severe hypothyroidism

Gergics Marin , Pham-Dobor Greta , Horváth-Szalai Zoltán , Kőszegi Tamás , Mezosi Emese , Bajnok Laszlo

Introduction: Significant hyponatremia may evolve in hypothyroidism, when however, elevated ADH levels have not been consistently demonstrated. On the other hand, it was shown that thyroid hormone substitution suppresses ADH, and its surrogate marker copeptin secretion. The aim of our present study was to investigate the possible humoral changes in a special model of resolution of short term severe hypothyroidism in differentiated thyroid cancer (DTC) patients.<p class="ab...