Searchable abstracts of presentations at key conferences in endocrinology

ea0005p220 | Steroids | BES2003

The relationalship of on-admission plasma cortisol to outcome in critical illness: a longitudinal prospective study

Jaiswal V , Baudouin S , Ball S

The hypothalamo-pituitary-adrenal (HPA) axis is essential component of the physiological stress response. Functional hypoadrenalism is a hypothetical contributor to mortality in the critically ill, though biochemical evidence for this is conflicting. Most studies have shown that 'high' random plasma cortisol in the first 24 hours of illness is associated with a high mortality. However, these data may be confounded by increased severity of illness in high mortality cohorts. Giv...

ea0003p100 | Diabetes & Metabolism | BES2002

A novel gender dimorphism in the response of the gonadal axis to critical illness

Jaiswal V , Baudouin S , Ball S

A gender-related bias in survival rates has been demonstrated in rodent models of critical illness. Sex steroids have differential effects on metabolic, immune and cardiovascular end points which may underlie these observations. The hypothalamo-pituitary-gonadal (HPG) axis response to critical illness in humans is poorly characterised. We have conducted a prospective study to characterise this response in the context of heterogeneous disease severity and disturbances in overal...

ea0003p290 | Thyroid | BES2002

Audit of the management of maternal hypothyroidism in pregnancy: Implications for service provision

Hannon T , Sturgiss S , Ball S

Maternal thyroxine (T4) deficiency is associated with adverse outcome for mother and infant such that selective screening has been advocated. Thyroid hormone production increases in pregnancy, T4-dependent patients requiring increased treatment. To highlight aspects of current service delivery and guide service development, we audited management of pregnant women requiring T4 in our city over one year.Cases were identified retrospectively through a data...

ea0019p366 | Thyroid | SFEBES2009

Anticonvulsant induced central hypothyroidism

Mettayil J , Quinton R , Ball S

Since the observation in 1961, that phenytoin treatment caused a reduction in protein bound iodine, the effect of various anticonvulsants on the thyroid hormones and in causing sub clinical and overt hypothyroidism has been a matter of debate. There are no reports linking newer antiepileptics like lamotrignine to thyroid hormone abnormalities. We report three patients who developed overt hypothyroidism while on treatment with Primidone, Lamotrignine and Carbamazepine respectiv...

ea0007p248 | Clinical case reports | BES2004

X-linked hypopituitarism: clinical and biochemical features of a rare cause of short stature

Barber T , Cheetham T , Ball S

Familial hypopituitarism is a heterogeneous group of disorders with variable clinical, biochemical and genetic characteristics. X-linked forms have been described in rare kindreds, though clinical and molecular features are not well defined. We present a case of X-linked hypopituitarism in a young male.The patient, currently 39 years, had an early course complicated by neonatal jaundice, seizures and subsequent failure to thrive. Hypothyroidism was diagn...

ea0007p250 | Clinical case reports | BES2004

Osteomalacia precipitated by growth hormone treatment in the adult: increased bone turnover unmasking occult vitamin D deficiency

Abouglila K , Miller M , Ball S

Growth Hormone (GH) deficiency in the adult is associated with sub-optimal bone mineral density (BMD) and reduced bone turnover. GH replacement therapy results in increased bone turnover and new bone formation with biphasic changes in BMD: We report a case in which the anabolic effects of GH on bone precipitated profound Vitamin D (Vit D) deficiency.The patient 56-year-old man with panhypopituitarism following treatment for acromegaly commenced adult GH ...

ea0005p16 | Clinical Case Reports | BES2003

Recurrent ovulation from an ovo-testis in 46XX/47XXY (mosaic) hermaphroditism: Serial high-resolution ultrasound characterisation

Barber T , Ball S , Elliott S

An ovo-testis (a gonad showing aspects of both ovarian and testicular function) occurs in some 60% of true hermaphrodites. They may be located in the labio-scrotal folds, inguinal canal or abdomen and are often removed prior to or shortly after the onset of puberty. Though the potential for ovulatory function within such a gonad is acknowledged, it is rarely witnessed and there are few detailed descriptions of the phenomenon. We describe serial observations of this process in ...

ea0005p97 | Diabetes, Metabolism and Cardiovascular | BES2003

Altered insulin sensitivity and secretion in sotos syndrome

Nag S , Bennett S , Gerrard J , Walker M , Ball S

Background: Sotos syndrome is an uncommon condition characterised by rapid growth, large body size and acromegaloid facies.There is limited data on metabolic abnormalities in Sotos syndrome.Aims: We investigated insulin sensitivity and secretion rates in a 22 year old girl with Sotos syndrome, prompted by the observation of a flat glucose response after an oral glucose challenge.Methods: Glucose tolerance was assessed with a 75g 2-h oral glucose tolerance test (OGTT), ...

ea0002p12 | Clinical case reports | SFE2001

Severe hyperandrogenism with polycythaemia: use of metformin as a therapeutic and diagnostic tool

Senior P , Ball S , Baylis P , Quinton R

Polycystic ovarian syndrome (PCOS) is the commonest cause of hyperandrogenism in women. Severe hyperandrogenism or virilisation, however, suggest the need to consider rarer causes e.g. Cushing's, congenital adrenal hyperplasia and androgen-secreting tumours. Here we present a case of PCOS where the remarkable response of severe hyperandrogenism with polycythaemia to metformin excluded these rarer causes without the need for complex or invasive investigation.<p class="abste...

ea0029p1368 | Pituitary Clinical | ICEECE2012

Hyponatraemia in aneurysmal subarachnoid haemorrhage is due to the syndrome of inappropriate antidiuresis and acute glucocorticoid deficiency

Hannon M. , Behan L. , Rogers B. , Sherlock M. , Smith D. , Agha A. , Ball S. , Thompson C.

Hyponatraemia is the most common electrolyte abnormality following subarachnoid haemorrhage (SAH). Retrospective data suggests that the Syndrome of Inappropriate Antidiuresis (SIAD) is the most common cause, although glucocorticoid deficiency and rarely cerebral salt wasting may also cause hyponatraemia.We prospectively studied 100 patients (61% female, median age 53 (range 16–82)) with non-traumatic aneurysmal SAH. Each patient had plasma sodium (p...