Searchable abstracts of presentations at key conferences in endocrinology

ea0063p1123 | Reproductive Endocrinology 2 | ECE2019

Study of the anti-inflammatory effects of dihydrotestosterone in human vaginal smooth muscle cells

Maseroli Elisa , Cellai Ilaria , Corno Chiara , Rastrelli Giulia , Filippi Sandra , Comeglio Paolo , Amoriello Roberta , Ballerini Clara , Sarchielli Erica , Morelli Annamaria , Maggi Mario , Vignozzi Linda

Inflammation is hypothesized to play an important role in several diseases associated to the female genital tract and dihydrotestosterone (DHT) has shown immunomodulatory protective effects in experimental models of chronic inflammation. In the present study we aimed to evaluate the potential anti-inflammatory effects of DHT in a model of smooth muscle cells (hSMCs) isolated from human vagina biopsies and their potential role as APCs (Antigen Presenting Cells), crucial for the...