Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep133 | Bone and Calcium | ECE2020

Prevalence and determinants of radiological vertebral fractures in a cohort of patients with Klinefelter syndrome

Vena Walter , Pizzocaro Alessandro , Amer Myriam , Indirli Rita , Maffezzoni Filippo , Ferrante Emanuele , Delbarba Andrea , Balzarini Luca , Ferlin Alberto , Mantovani Giovanna , Lania Andrea , Mazziotti Gherardo

Klinefelter syndrome (KS) is a frequent form of male hypogonadism that may be associated with a series of comorbidities potentially affecting quality of life and survival. As a matter of fact, KS was shown to negatively impact skeletal health. However, the studies so far published on this topic were mainly focused on evaluation ofbone mineral density (BMD) and bone microstructure, whereas data on fracture risk are still lacking. In this cross-sectional study, we evaluated for ...

ea0070aep578 | Pituitary and Neuroendocrinology | ECE2020

Association between sagittal spine imbalance and radiological vertebral fractures in acromegaly: Does it reflect a pathophysiological link?

Cellini Miriam , Biamonte Emilia , Trenti Nicoletta , Mazza Massimiliano , Milani Davide , Ferrante Emanuele , Lavezzi Elisabetta , Mantovani Giovanna , Arosio Maura , Fornari Maurizio , Balzarini Luca , Lania Andrea , Mazziotti Gherardo

Chronic exposure to GH hypersecretion may alter the physiological balance of the spine through inducing degeneration of intervertebral discs and impaired trophism of facet joints. Moreover, GH in excess may also cause profound deterioration in bone microstructure with consequent increase in risk of fragility vertebral fractures (VFs). In this cross-sectional study,we evaluated for the first time in acromegaly the association between spine imbalance and VFs. Thirty-eight patien...

ea0081p305 | Calcium and Bone | ECE2022

Reliability of who fracture risk assessment tool (frax) and bone mineral density in predicting fractures in cancer patients under hormone deprivation therapies: a real-world clinical study

Vena Walter , Piccini Sara , Pedersini Rebecca , Carrone Flaminia , Cosentini Deborah , Zucali Paolo , Torrisi Rosalba , Brunetti Alessandro , Pigni Stella , Maroldi Roberto , Balzarini Luca , Lania Andrea Gerardo , Berruti Alfredo , Berruti Gherardo

Background: Skeletal fragility is an important clinical issue in women with early-stage breast cancer and men with non-metastatic prostate cancer under hormonal hormone deprivation therapies (HDTs). Vertebral fractures (VFs) have been reported in a remarkable number of subjects exposed to HDT especially when the diagnosis of fractures is performed by a radiological and morphometric approach. Notably, prediction of fractures in this clinical setting is a challenge and determina...