Searchable abstracts of presentations at key conferences in endocrinology

ea0031cmw2.5 | How Do I Do It? | SFEBES2013

How and when do I induce puberty in males?

Banerjee Indi

Induction of puberty may be required in boys, if puberty is either delayed or arrested. Boys with delayed puberty are often significantly concerned about their physical immaturity, short stature and perceived difference in appearance from peers. The commonest cause of delayed puberty is constitutional delay of growth and puberty (CDGP), a relatively benign condition. However, hypergonadotrophic hypogonadism due to Klinefelter syndrome and hypogonadotrophic hypogonadism (HH) du...

ea0045oc2.2 | Oral Communications 2- CME | BSPED2016

A novel mutation in thyroid pathobiology in families with X-linked intellectual disability?

Chinoy Amish , Banerjee Indi

Although congenital hypothyroidism is sporadic in the majority, recessive and X-linked inheritance can also occur in monogenic disorders. In familial cases, the finding of genetic variation could identify specific phenotypes and unravel thyroid pathobiology.We describe three siblings born to non-consanguineous parents. The index case, a boy, presented at 1 year of age with severe developmental delay, expressive aphasia and hypotonia. Thyroid function sho...

ea0058oc8.1 | Oral Communications 8 | BSPED2018

Five year outcomes in a cohort with hypoglycaemia due to congenital hyperinsulinism

Al-Hashmi Laila , Estebanez Maria , Banerjee Indi

Background: Congenital hyperinsulinism (CHI) is one of the commonest causes of recurrent hypoglycaemia due to excess production of insulin in infancy and results in neurological impairment in a third to a half of patients. The treatment of CHI is often complex and complicated by side effects; the medium-term effects of such treatment are not known.Aim: To describe five year clinical outcomes in a cohort of infants with CHI.Methods:...

ea0078p44 | Miscellaneous | BSPED2021

Interpretation of CGM-measured nocturnal hypoglycaemia in congenital hyperinsulinism

Yang Leyi , Worth Chris , Salomon Estebanez Maria , O‘Shea Elaine , Banerjee Indi

Background: Congenital Hyperinsulinism (CHI) is characterised by dysregulated and excess secretion of insulin leading to severe hypoglycaemia. Monitoring of glucose levels is essential in this condition as prolonged hypoglycaemia can cause life-threatening complications such as permanent neurological impairment. Interstitial glucose monitoring by continuous glucose monitoring (CGM) devices can identify nocturnal hypoglycaemia retrospectively through data analysis. Analysis can...

ea0036P59 | (1) | BSPED2014

Is there a role for medical management in childhood obesity? A review of the Manchester Metabolic Obesity Service

Tan Sherie , Skae Mars , Banerjee Indi , Padidela Raja , Ehtisham Sarah , Mughal Zulf , Clayton Peter , Patel Leena

Background: Childhood obesity is a growing problem worldwide, with serious effects on child health. Obese children are at a higher risk of developing metabolic co-morbidities earlier in life (WHO, 2013). Manchester has worse than national average levels of obesity, with an estimated 14 000 obese children (PHE, 2014).Aims and methods: A retrospective case note analysis of 117 obese paediatric patients, seen in our service between March 2012 and 2014, was ...

ea0058p023 | Growth | BSPED2018

Optimising diagnostic performance of IGF-I and IGFBP-3 measurement: importance of reference range and cut-off value

Al-Hashmi Laila , Manfredonia Claire , Banerjee Indi , Tetlow Lesley , Murray Philip , Clayton Peter

Background: The diagnosis of growth hormone deficiency (GHD) is based on a combination of clinical suspicion supported by growth hormone stimulation testing. IGF-1 and IGFBP-3 are used as supportive markers. Reports over the last decade have examined the performance of IGF-I and IGFBP-3 in the diagnosis of GHD. It is important that each unit evaluates the utility of these markers in the assay used by their laboratory based on relevant normative data.Aim:...

ea0023oc1.1 | Oral Communications 1 | BSPED2009

Cholesterol and apolipoprotein levels in a cohort of girls with Turner syndrome, and the effect of GH therapy

Gardner Chris , Garden Anne , Didi Mohammed , Newland Paul , Banerjee Indi , Blair Jo

Introduction: Ischaemic heart disease occurs seven times more frequently in women with Turner syndrome (TS) than the normal population. Adult TS subjects have raised serum cholesterol (Ch). In our service we measure Ch, apolipoprotein A1 (APA) and B (APB) annually in TS patients aged >5 years as APB:APA in childhood is a strong predictor of cardiovascular risk in adult life. Little is known about lipid profiles or the effects of GH or oestrogen (E2) in childhood...

ea0023oc5.3 | Oral Communications 5 | BSPED2009

Young persons' weight management service: a service users' evaluation

Williams Marc , Kendall Debbie , Gleeson Helena , Amin Rakesh , Banerjee Indi , Patel Leena , Clayton Peter , Hall Catherine

Background: Obese young people are likely to suffer significant morbidity in adult life. Successful intervention during adolescence may have far-reaching benefits. Evidence is emerging that patient-responsive clinical services may deliver improved outcomes.Aims: To assess the perceptions of obese young people about weight and weight-management services.Method: Annonymised, postal questionnaire survey of 116 obese young people (9&#1...

ea0023p36 | (1) | BSPED2009

What do young people think about seeing the doctor alone in paediatric endocrine clinics?

Gleeson Helena , O'Shea Elaine , Jones Julie , Patel Leena , Hall Catherine , Banerjee Indi , Amin Rakesh , Clayton Peter

Background: Seeing the doctor alone has been associated with a better outcome following transition to adult services.Methods: A simple questionnaire was designed for young people (YP) to enquire about being seen alone in paediatric endocrine clinics.Results: The questionnaire was administered to 72 YP young people (37 male) with long term endocrine conditions. The mean age was 15.5 (2.5). 10% of YP thought they should be offered th...

ea0045oc5.5 | Oral Communications 5- Endocrine | BSPED2016

The performance of early childhood Human Chorionic Gonadotrophin (HCG) testing to investigate male undervirilisation

van Geffen Joshua , Chinoy Amish , Ivison Fiona , Tetlow Lesley , Banerjee Indi

Background: The 3 day human chorionic gonadotrophin (HCG) test is commonly performed to investigate male undervirilisation. However, the utility of routine HCG testing for male undervirilisation in early childhood and correlation with pubertal progress is unclear.Aims: To review performance of the 3 day HCG test for diagnosis and outcomes.Methods: Standard 3 day HCG test data were analysed in 130 boys of age <3 years with under...