Searchable abstracts of presentations at key conferences in endocrinology

ea0039ep81 | Miscellaneous/other | BSPED2015

Pilot study on the utility and acceptability of video animation as a delivery method for educational materials for families and carers of patients with congenital hyperinsulinism in infancy

Rodgers Elizabeth , Rigby Lindsey , Dunne Mark , Banerjee Indraneel , Cosgrove Karen

Introduction: To prevent neurological damage caused by congenital hyperinsulinism (CHI), hypoglycaemia must be avoided and treated promptly. Education of parents, carers and families of patients with CHI (PCFs) about the causes and consequences of CHI may help to reduce severity of hypoglycaemia due to earlier correction of blood glucose levels. We aimed to determine whether video animations could be used to improve understanding of CHI among PCFs, and the acceptability of thi...

ea0036P64 | (1) | BSPED2014

Cellular proliferation is increased in both the lesion and non-lesion pancreas in focal congenital hyperinsulinism

Mohamed Zainaba , Han Bing , Newbould Melanie , Cosgrove Karen , Padidela Raja , Banerjee Indraneel , Dunne Mark J

Introduction: Focal congenital hyperinsulinism (F-CHI) is caused by dual-hit pathology, comprising a paternally-inherited ABCC8/KCNJ11 mutation and somatic loss of the maternal allele at chromosome 11p15. This leads to dysregulation of insulin secretion and β-cell overgrowth with a focal domain.Objectives: To compare the proliferative index (PI) of the F-CHI lesion and non-lesion pancreatic tissues to age-matched control pancreata and insul...

ea0027p77 | (1) | BSPED2011

Octreotide treatment for congenital hyperinsulinism can cause hepatitis

Avatapalle Bindu , Rigby Lindsey , Patel Leena , Ehtisham Sarah , Skae Mars , Padidela Raja , Banerjee Indraneel , Clayton Peter

Introduction: Congenital hyperinsulinism (CHI) is a rare condition of dysregulated insulin secretion causing hypoglycaemia. Oral Diazoxide is used as first line therapy for CHI. In those who are Diazoxide unresponsive, subcutaneous Octreotide is used as second line treatment. Octreotide has recognised side effects of biliary stasis. Additionally, we report hepatitis as a complication of Octreotide therapy in a child with CHI.Case report: A neonate with C...

ea0027p81 | (1) | BSPED2011

An audit of diazoxide prescriptions in children with congenital hyperinsulinism: preliminary recommendations

Dimitriu Alma Iulia , Avatapalle Bindu , Rigby Lindsey , Banerjee Indraneel , Patel Leena

Introduction: Congenital hyperinsulinism (CHI) is characterised by abnormally regulated and excessive insulin secretion by pancreatic β cells. First line management includes an oral suspension of Diazoxide but a standardised formulation is not universally employed. Anecdotal evidence suggests that different formulations can alter the management of glucose levels. Lack of glucose control can lead to permanent brain damage and adversely affect neuro development.<p class...

ea0039oc8.4 | Oral Communications 8 | BSPED2015

Predictors of insulin resistance and the effect of Metformin treatment in obese paediatric patients

Gallen Hannah , Banerjee Indraneel , Clayton Peter E , Ehtisham Sarah , Padidela Raja , Patel Leena , Salsbury Louise , Skae Mars

Introduction: Paediatric obesity is a growing concern for the health service. There is currently no consensus for routine screening of metabolic profiles and medical treatment in obese paediatric patients.Aims/methods: We aimed to determine medium-term outcomes of Metformin treatment on BMI, glucose and insulin levels in obese paediatric patients. In a retrospective review, data were collected from obese paediatric patients on Metformin for insulin resis...

ea0039ep86 | Miscellaneous/other | BSPED2015

The use of glucagon in the treatment of hypoglycaemia due to congenital hyperinsulinism

Jadawji Chandni , Estebanez Maria , Padidela Raja , Bowden Louise , Rigby Lindsey , Kinzell John , Cosgrove Karen , Dunne Mark , Banerjee Indraneel

Background: Congenital hyperinsulinism (CHI) can cause severe hypoglycaemia with consequent adverse neurodevelopment. Continuous glucagon infusion (CGI) through intravenous and subcutaneous routes has been utilised to achieve glycaemic stability, but the efficacy has not been reported systematically in a CHI cohort.Aim: We aimed to investigate the efficacy and safety profile of CGI in the management of hypoglycaemia due to CHI.Meth...

ea0039ep92 | Obesity | BSPED2015

Psychological sequelae in obese paediatric patients and predictors for weight loss

Gallen Hannah , Banerjee Indraneel , Clayton Peter E , Ehtisham Sarah , Nicholson Jacqueline , Padidela Raja , Patel Leena , Tobin Hannah , Skae Mars

Introduction: There is limited data on the psychological sequelae of obesity in paediatric patients.Aims/methods: We aimed to assess the prevalence of psychological comorbidities in obese paediatric patients. Internationally validated self-report questionnaires were offered to 19 patients and their parents from a tier three paediatric obesity clinics. These included the Paediatric Index of Emotional Distress (PI-ED); Beck Youth Inventory exploring self-p...

ea0039oc6.1 | Oral Communications 6 | BSPED2015

Somatostatin-expressing cells contribute to the pathobiology of atypical congenital hyperinsulinism in infancy

Han Bing , Newbould Melanie , Batra Gauri , Cheesman Edmund , Craigie Ross , Mohamed Zainab , Rigby Lindsey , Padidela Raja , Skae Mars , Cosgrove Karen , Dunne Mark , Banerjee Indraneel

Background: Atypical congenital hyperinsulinism in infancy (CHI-A) represent patients who generally present symptoms of hypoglycaemia later in the neonatal period, are poorly responsive to medical intervention and have no known genetic cause of disease. Our objective was to compare the expression profiles of insulin and somatostatin in islets from patients with CHI-A, diffuse CHI (CHI-D) and age-matched control tissue.Methods and materials: CHI tissues w...

ea0039p2 | (1) | BSPED2015

Islet cell proliferation is inappropriately maintained in the pancreas of children with congenital hyperinsulinism in infancy

Han Bing , Newbould Melanie , Cheesman Edmund , Batra Gauri , Craigie Ross , Mohamed Zainab , Rigby Lindsey , Padidela Raja , Skae Mars , Cosgrove Karen , Dunne Mark , Banerjee Indraneel

Background: In diffuse CHI (CHI-D) insulin release is uncontrolled due to mutations in the ABCC8/KCNJ11 genes. Increased rates of cell proliferation have also been reported, but the mechanisms responsible for this are unknown. We hypothesized that this may arise as a consequence of failure to terminate proliferation in the neonatal period. Here, we examined the proliferative index (PI) of islet cells in CHI-D patients and compared this with focal CHI (CHI-F) ...

ea0039ep96 | Other | BSPED2015

A distinct population of islet cells defines diffuse congenital hyperinsulinism in infancy but not other forms of the disease

Han Bing Bing , Newbould Melanie , Batra Gauri , Cheesman Edmund , Craigie Ross , Mohamed Zainab , Rigby Lindsey , Padidela Raja , Skae Mars , Cosgrove Karen , Dunne Mark , Banerjee Indraneel

Background/hypothesis: Congenital hyperinsulinism in infancy (CHI) mainly arises from mutations in ATP-sensitive potassium channel genes. However, the expression pattern of defects can be markedly diverse. In diffuse CHI (CHI-D) all islet cells express gene defects, whereas patients with focal CHI (CHI-F) only express defects in a localised region of islet cells due to loss of a maternally-imprinted locus. Here, we examined the properties of a novel population of CHI islet cel...