ea0094oc2.6 | Endocrine Cancer and Late Effects | SFEBES2023
Manivannan Selvambigai
, Banga Davina
, Kocbiyik Merve
, Read Martin
, Zha Ling
, Brookes Katie
, Nieto Hannah
, McCabe Chris
, Smith Vicki
The progression of thyroid cancer is dependent on cell motility, a highly complex process that involves the co-ordination of multiple signalling pathways, cell adhesion, and actin dynamics. The proto-oncogene pituitary tumor-transforming gene (PTTG)-binding factor (PBF/PTTG1IP) potently stimulates thyroid cancer cell migration and invasion via PBF phosphorylation by Src kinase at residue Y174. Recent phosphoproteomic and RNA-Seq analyses revealed that upregulation of PBF in Nt...