Searchable abstracts of presentations at key conferences in endocrinology

ea0011s83 | Management of Graves' ophthalmopathy | ECE2006

Alternative immunomodulatory therapies for Graves’ ophthalmopathy

Banga JP

Advances in understanding the pathogenesis of autoimmune diseases is leading to development of new targeted therapies, with the resultant improvements in the management of the patients. Autoimmunity to the TSH receptor is the main cause of Graves’ disease and components of this disorder are the extrathyroidal complications which include Graves’ ophthalmopathy and pretibial dermopathy. Recent studies in Graves’ ophthalmopathy implicate an additional target antige...

ea0019p374 | Thyroid | SFEBES2009

Clonal relationships between TSH receptor stimulating antibodies illustrate the effect of hypermutation on antibody function

Gilbert J , Padoa C , Larsen S , Hampe C , Dagdan E , Hegedus L , Dunn-Walters D , Banga JP

There is a paucity of information regarding the genetic and somatic mutation events that lead to the production of pathogenic thyroid stimulating antibodies (TSAbs) in Graves’ disease. We have previously isolated two murine monoclonal antibodies (KSAb1 and KSAb2) with potent TSAb activity that demonstrate subtle differences in their interaction with the thyrotropin receptor (TSHR). Analyses of the variable region genes of the heavy and light chains of these TSAbs were per...