Searchable abstracts of presentations at key conferences in endocrinology

ea0005p128 | Endocrine Tumours and Neoplasia | BES2003

CYP27b and CYP24 expression combine to determine 1,25 Dihydroxyvitamin D3 insensitivity in breast cancer cells

Townsend K , Banwell C , Stewart P , Hewison M , Campbell M

To dissect mechanisms which result in 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) insensitivity we have compared the antiproliferative actions of 1,25(OH)2D3 in a range of malignant breast cell lines (ZR-75-1, T-47D, MCF-7, MCF-7Res and MDA-MB-231) and the non-malignant breast epithelial cells MCF-12A cells. All the malignant cell lines displayed greater resistance than MCF-12A cells to 1,25(OH)2D3. For ex...