Endocrine Abstracts

Introduction: Pseudohypoparathyroidism type la (PHP-1a) is an uncommon disorder that results from an inactivating mutation in the GNAS gene. It can present with resistance to several hormones, in addition to parathyroid hormone (PTH). A characteristic skeletal phenotype also results, referred to as Albright’s hereditary osteodystrophy, that occurs because of the crucial role of Gs-α signaling in the growth, differentiation, and structure of these tissues.<p class...