Searchable abstracts of presentations at key conferences in endocrinology

ea0029p83 | Adrenal cortex | ICEECE2012

Impact of reference values and published thresholds on clinically relevant cut-offs

Brossaud J. , Barat P. , Georges A. , Corcuff J.

The adrenal function of children is investigated similarly to adults’ using at rest (basal) and after testing serum cortisol concentration ((F)). di Iorgi et al. (JCEM 95:2132) showed a good diagnostic accuracy of glucagon testing investigating (F) increase. We retrospectively addressed the relevance of using, in children with short stature tested for GH deficiency, 1/ the normal reference range of our assay for basal (F) and 2/ the threshold provided by di Iorgi et al. o...

ea0011p387 | Diabetes, metabolism and cardiovascular | ECE2006

Androgen regulation of hepatic glucocorticoid metabolism in obese Zucker rats

Livingstone DEW , Barat P , McDonnell CR , Walker BR , Andrew R

Obesity is associated with decreased hepatic reactivation of glucocorticoids (Gc) by 11β-hydroxysteroid dehydrogenase type 1 (11HSD) and increased metabolism of glucocorticoids by hepatic A-ring reductases, which may contribute to activation of the hypothalamic-pituitary-adrenal axis. Androgen action encourages central obesity and increased metabolic complications, possibly by altering Gc metabolism.This study investigates the role of gonadal androg...