Searchable abstracts of presentations at key conferences in endocrinology

ea0069p68 | Poster Presentations | SFENCC2020

Refractory cyclical cushing’s – clinical challenges

Banu Zeenat , Eltayeb Randa , Aziz Umaira , Eldigair Hiba , Tickle Eliane , Khoo Bernard , Yousseif Ahmed , Al-barazi Sinan , Karra Efthimia

Case history: Cyclical Cushing’s is a very rare disease with rhythmic fluctuations in cortisol production with or without phenotypic features. It is a very challenging entity to diagnose. The low index of clinical suspicion is key for timely diagnosis and prevention of long-term complications. A 66 years old male presented with intermittent, episodic bilateral leg swelling and reversible weight gain of ˜6 kg following these episodes. Background history entailed femor...

ea0081p175 | Pituitary and Neuroendocrinology | ECE2022

Low post-operative cortisol after TSS for pituitary surgery predicts short term but not long term remission

Karunakaran Vanitha , Okasha Mohamed , W Thomas Nick , Barazi Sinan , Maratos Eleni , C Whitelaw Benjamin , Gilbert Jackie , V Carroll Paul , Shapey Jonathan , J B Aylwin Simon

Background: It is generally accepted that a post-operative cortisol of <50 nmol/l is a good predictor of long-term remission following trans-sphenoidal surgery (TSS).Aim: We wished to determine the rate of late recurrence and need for consequent intervention in patients who had initial biochemical remission after TSS for pituitary dependent Cushing’s.Methods: We performed a retrospective analysis of our patients who underw...

ea0070aep560 | Pituitary and Neuroendocrinology | ECE2020

Proliferation index (Ki67) is a powerful predictor of recurrence in pituitary adenoma

Logan Ellis Hugh , Xekouki Evi , King Andy , Thomas Nick , Barazi Sinan , Maratos Eleni , Bullock Peter , Whitelaw Benjamin , Gilbert Jackie , Aylwin Simon

Introduction: In 2017 the term ‘Atypical adenoma’ was removed from the WHO classification, and ‘High-risk adenomas’ was introduced as a term to classify those with rapid growth, radiological invasion, and a high Ki-67 proliferation index. In this retrospective cohort study we have sought to identify the clinical and histological characteristics which are associated with worse outcomes.Methods: Data: We created a dataset of 1793 pa...

ea0031p158 | Neoplasia, cancer and late effects | SFEBES2013

Pituitary metasases: patients presenting with cranial nerve palsies and diabetes insipidus: a single centre experience

Salaris Paola , Kordbacheh Tiana , Whitelaw Ben , Mustafa Omar , Visca Anna , Thomas Nick , Bullock Peter , Barazi Sinan , Landau David , King Andrew , Hampton Timothy , Gilbert Jackie , McGregor Alan , Aylwin Simon

Background: Pituitary metastases are a rare complication of systemic malignancy. The most common presentations of pituitary masses include visual field defects, headaches, and hypopituitarism, but cranial nerve palsies and diabetes insipidus are also recognised although unusual. We aimed to determine if these were more frequently associated with pituitary metastasis.Methods: We conducted a review of 944 patients undergoing pituitary surgery from a teachi...

ea0031p257 | Pituitary | SFEBES2013

Endocrine remission of Cushing's disease after endoscopic trans-sphenoidal surgery: Retrospective review of a single centre experience

Kennard Devon , Whitelaw Ben , Dworakowska Dorota , Thomas Nick , Barazi Sinan , Bullock Peter , King Andrew , Hampton Tim , Sherwood Roy , Buchanan Charles , Gilbert Jackie , McGregor Alan , Aylwin Simon

Background: Cushing’s disease is caused by corticotroph tumours of the pituitary gland and the standard first-line treatment is trans-sphenoidal surgery. Published data from other centres describes post-operative endocrine remission achieved in 50–90% of cases.Table 1 Remission (cortisol <50)Cortisol (50–150 nmol/l)<td alig...