Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep484 | Thyroid | ECE2020

Clinical presentation and prognosis of patients with medullary thyroid cancer

de Cicco Federica , Modica Roberta , Barba Livia , Bottiglieri Filomena , Minotta Roberto , Faggiano Antongiulio , Colao Annamaria

Medullary thyroid carcinoma (MTC) is a rare type of tumor that originates from parafollicular C-cells and accounts for 3–4% of all malignant thyroid neoplasms. MTC presents as sporadic (75–80%) or inherited tumors (20–25%). Hereditary MTC is part of multiple endocrine neoplasia type 2 (MEN2). Aim of the study was to describe clinical presentation, prognosis and therapy of sporadic MTC patients. Sixty-seven patients (pts) with histologically confirmed MTC refe...

ea0081p313 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Obesity and obesity-related diseases as a new clinical features in 3q27.3 microdeletion syndrome involving adipoq gene: a case study

De Brasi Davide , Novizio Vincenzo , Barba Livia , Scarano Elisabetta , Serino Domenico , Novizio Roberto , Della Monica Matteo , Petillo Roberta , Scavuzzo Francesco

Introduction: Adipose tissue is recognized as an important endocrine organ, secreting many endocrine factors. Adiponectin is the most abundant peptide released into circulation, encoded by ADIPOQ gene localized in chromosome 3q27.3. Adiponectin decreases intracellular ceramide, implicated in insulin resistance, inflammation and atherosclerosis. It stimulates fatty acid oxidation in skeletal muscle and inhibits glucose production in the liver. Hypo-adiponectinemia plays a centr...