Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep229 | Calcium and Bone | ECE2022

Multifactorial causes of secondary osteoporosis: a case report

Fortes Delfina Indira , Barbosa Ana Paula

Introduction: Osteoporosis is a metabolic bone disease, characterized by reduction and changes in the bone mass quantity and quality, leading to an increased risk of fractures. It can be divided in primary (postmenopausal or senile), secondary and idiopathic. In the presence of osteoporotic fractures, particularly in men before the age of 65, it is essential to investigate the presence of secondary causes in order to establish an etiological therapy.Case...

ea0090ep190 | Calcium and Bone | ECE2023

Denosumab in the treatment of fracturary osteoporosis: the double effect on bone and glycemic metabolism

Cosme Ines , Nobre Ema , Barbosa Ana Paula

Background: Denosumab (Dmab) is a human monoclonal antibody with an anti-reabsorptive bone effect, used in osteoporosis treatment. It is also suggested that Dmab may improve glucose tolerance through the reduction of hepatic insulin resistance. Some studies have suggested that insulin sensitivity and glycemia can influence bone metabolism.Aims: To evaluate the relationship between bone turnover markers (BTM) and insulin resistance and glycemia in fractur...

ea0070aep222 | Bone and Calcium | ECE2020

Testosterone, estradiol and 25-hydroxyvitamin D effects at the proximal femur in 3D analysis from a standard 2D DXA scans of adult men

Rui Mascarenhas Mário , Barbosa Ana Paula , Winzenrieth Renaud

Sex steroid hormones play a pleomorphic role in preservation of BMD. The BMD, the blood circulating 25-hydroxyvitamin D [25(OH)D], testosterone and estradiol levels may decline with age and to contribute to bone fragility. Low vitamin D is associated with increased falls number and fractures.Recently, a new software solution, 3D-SHAPER - allows measurements of both trabecular and cortical bone as well as 3D images -, it incorporates a model-bas...

ea0070aep238 | Bone and Calcium | ECE2020

Osteoporotic bone fracture hiding a rare sex chromosome disorder: Case report

Indira Fortes Delfina , Rui Mascarenhas Mario , Barbosa Ana Paula

Introduction: The XXYY Syndromeis an extremely rare sex chromosomal disorder characterized by the presence of extra X and Y chromosomes, and clinically by tall stature, dysfunctional testes associated with infertility and hypogonadism, cognitive, affective and social functioning impairments, global developmental delay, and an increased risk of congenital malformations.Case report: A 46-year-old man was referred to theFracture Osteoporosis OutpatientClini...

ea0063p1028 | Interdisciplinary Endocrinology 2 | ECE2019

Impact of hormonal factors in the genesis of sarcopenia

Mascarenhas Mario Rui , Barbosa Ana Paula , Fortes Indira , Ferreira Joana , Bicho Manuel

The European Working Group on Sarcopenia in Older People (EWGSOP2) defined in 2018 ‘sarcopenia as muscle disease (muscle failure), with low muscle strength overtaking the role of low muscle mass as a principal determinant’; sarcopenia increases risk of falls and fractures, impairs ability to perform activities of daily living, leads to mobility disorders and low quality of life and death. The diagnosis is confirmed by low muscle quantity or quality. The muscle quanti...

ea0049ep232 | Bone & Osteoporosis | ECE2017

May serotonin metabolism polymorphisms 5HTTVNTR and 5HT2A have a clinical impact in osteoporosis development?

Simoes Raquel , Freitas Joana , Barbosa Ana Paula , Mascarenhas Rui , Bicho Manuel

Objectives: To study the association of serotonin transporter gene (SLC6A4) polymorphism 5HTTVNTR and serotonin receptor 2A polymorphism 5HT2A_T102C with bone mineral density and metabolic parameters of bone remodelling.Materials and methods: BMD (g/cm2) was measured by DEXA in 105 post-menopausal women: 35 with normal BMD (age=58.30±1.33 years; BMI=28.18 [19.13-39.87] kg/m2) and 70 with osteoporosis (age=68.30±1.09 years; BMI=28.90 ...

ea0049ep234 | Bone & Osteoporosis | ECE2017

Beta-2 adrenergic receptor (ADRB2) gene polymorphism Arg16Gly as risk factor for osteoporosis

Simoes Raquel , Freitas Joana , Barbosa Ana Paula , Mascarenhas Mario , Bicho Manuel

Objectives: To study the association of Beta-2 adrenergic receptor (ADRB2) gene polymorphism Arg16Gly with bone mineral density and metabolic parameters of bone remodelling.Materials and methods: BMD (g/cm2) was measured by DEXA in 105 post-menopausal women: 35 with normal BMD (age=58.30±1.33 years; BMI=28.18 [19.13-39.87] kg/m2) and 70 with osteoporosis (age=68.30±1.09 years; BMI=28.90 [20.78-43.86] kg/m2). Met...

ea0081ep1172 | Late Breaking | ECE2022

Osteoporosis after menopause: interaction between genes related to iron metabolism and estradiol

Aguiar Laura , Ferreira Joana , Pereira Raquel Binda , Barbosa Ana Paula , Rui Mascarenhas Mario , Faustino Paula , Inacio Angela , Bicho Manuel

Introduction: Osteoporosis is a common metabolic bone disease characterized by reduced bone mass and increased risk of fragility fractures. The pathogenesis of this disease is complex and influenced by multiple risk factors, where genetic factors play an important role. Menopause predisposes women to osteoporosis due to declining estrogen levels. Osteoporosis and iron metabolism have an important relationship. Iron overload suppresses osteoblast formation and stimulate osteocl...

ea0090ep78 | Adrenal and Cardiovascular Endocrinology | ECE2023

Primary bilateral macronodular adrenal hyperplasia: Is unilateral adrenalectomy enough?

Lopes-Pinto Mariana , Fialho Mafalda Pinho , Ricca Lacerda Nobre M Caetano Ema Paula , Rocha Jose , Barbosa Ana Paula

Introduction: Primary Bilateral Macronodular Adrenal Hyperplasia (PBMAH) represents <2% of causes of Cushing’s Syndrome (CS). Clinical course is insidious, with adrenal bilateral macronodules and gradual cortisol excess, only rarely presenting with overt CS. The pathophysiology remains unclear, however, hyperactivation of the cAMP/PKA pathway, in 77-87% of cases through aberrantly expressed G-protein coupled receptors (GPCRs), has been described. Despite being a benig...

ea0037ep294 | Calcium and Vitamin D metabolism | ECE2015

May the polymorphism of low molecular weight protein tyrosine phosphatase modulate metabolic and bone remodelling parameters associated with osteoporosis?

Freitas Joana , Monteiro Cristina , Barbosa Ana Paula , Batista Fatima , Laires Maria Jose , Bicho Manuel , Mascarenhas Mario Rui

Aims: To study the association of protein tyrosine phosphatase (LMW–PTP/ACP1) polymorphism with bone mineral density and metabolic parameters of bone remodelling.Methods: BMD (g/cm2) was measured by DEXA in 760 subjects: 448 normal BMD (359F/89M; 49.7±12.9 years; 30.2±5.4 kg/m2) and 312 osteoporosis (265F/47M; 63.9±10.4 years; 27.16±4.4 kg/m2). Metabolic bone remodelling parameters were analyzed: ...