Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep874 | Pituitary - Clinical | ECE2016

Discrepant GH and IGF-I values in the evaluation of treated acromegalic patients; an ongoing challenge. A meta-analysis

Kanakis George , Chrisoulidou Alexandra , Bargiota Alexandra , Efstathiadou Zoe , Papanastasiou Lamprini , Theodoropoulou Anastasia , Tigas Stylianos , Vassiliadi Dimitra , Tsagarakis Stylianos , Alevizaki Maria

Purpose: Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-I) are currently the principal biomarkers used to assess disease activity in acromegaly and any discrepancy between them renders interpretation of results inconclusive. The purpose of this study was to assess the frequency of discrepant results and identify parameters that might affect the emergence of this phenomenon.Methods: A systematic review of Medline and Scopus was performed (1987&...

ea0070ep135 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Comparison of two different dietetic approaches in obese and overweight patients with type 2 diabetes mellitus

Balamoti Christina , Bargiota Alexandra

Context: Weight reduction in obese patients with type 2 diabetes mellitus (T2DM) leads to hyperglycaemia improvement and reduces complications. Thus it is important to investigate the potential benefits of the use of different dietetic approaches on weight loss.Objective: To examine the efficacy of two different dieting methods on weight loss in patients with T2DM.Materials and methods: 30 participants with T2DM, 18 men and 12 wome...

ea0081ep329 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Metreleptin treatment in woman with familial partial lipodystrophy and severe hypertriglyceridemia

Barmpa Eleftheria , Pappa Dimitra , Bargiota Alexandra

Introduction: Metreleptin, a recombinant analogue of leptin, is the only drug available for the treatment of generalized or partial lipodystrophy. Familial partial lipodystrophy (FPL) is a rare genetic disorder characterized by selective loss of subcutaneous adipose tissue, ectopic fat deposition, decreased leptin levels, and varying metabolic disorders, which in some patients can be quite severe and life-threatening. We present here such a woman with FPL who is treated with m...

ea0063p617 | Diabetes, Obesity and Metabolism 2 | ECE2019

Liraglutide restores the hyperglycemic oxidative imbalance and induces the expression of CRH, UCN1, UCN2 AND UCN3 neuropeptides in macroendothelial cells

Gougoura Sofia , Bargiota Alexandra , Koukoulis Georgos N.

Introduction: Liraglutide treatment reduces cardiovascular complications in patients with diabetes mellitus (DM), which may imply a favorable impact on the endothelial function. The aim of the present study was to investigate in vitro the effect of liraglutide on endothelial redox balance and the parallel expression of CRH, UCN1, 2 and 3 neuropeptides, under normoglycemic and hyperglycemic conditions.Methods: Macroendothelial cell line EAhy926 w...

ea0049ep618 | Diabetes therapy | ECE2017

Liraglutide restores the hyperglycemia-induced endothelial oxidative stress in vitro

Gougoura Sofia , Bargiota Alexandra , Koukoulis Georgios N

Introduction: Diabetes is characterised by increased oxidative stress and an insufficient antioxidant response, which are crucial for the initiation and progression of atherosclerosis. GLP-1 agonists, used for the treatment of diabetes, are considered as cardioprotective agents but under that concept, there are limited data on their ability to influence the endothelial antioxidant response.Methods: In order to answer this question we studied the influenc...

ea0056p388 | Diabetes (to include epidemiology, pathophysiology) | ECE2018

Eating habits, food choices and physical activity in adult patients with type 1 diabetes mellitus

Barmpa Eleftheria , Tsiouma Christina , Bargiota Alexandra

Introduction: Eating habits, food choices and exercise affect glycaemic control in patients with Type 1 Diabetes Mellitus (T1DM). The purpose of this study was to evaluate eating behaviors, food choices and the level of physical activity in patients with T1DM.Methods/design: A random sample of 84 patients (M/F: 31/53) with T1DM, aged 34+11.9 years, living in central Greece, were individually interviewed. Food consumption was assessed by a semi-q...

ea0081oc1.2 | Oral Communications 1: Diabetes, Obesity, Metabolism and Nutrition 1 | ECE2022

Glucose control and mortality in critically Ill patients, based on real world evidence

Dafoulas George , Kalamaras Ilias , Votis Konstantinos , Bargiota Alexandra

Objective: Published results of reduced morbidity and mortality with tight Glycemic Control of critical patients could not be reproduced in large prospective trials. Glycemic goals according to current respective guidelines include a target blood glucose range 140-180 mg/dl, while lower blood glucose targets may be appropriate for some patients. This study aims to provide real world evidence to this field.Methods: We performed a retrospective study using...

ea0063p530 | Diabetes, Obesity and Metabolism 2 | ECE2019

Vitamin B12 and gestational diabetes mellitus

Kouroglou Eleni , Anagnostis Panagiotis , Daponte Alexandros , Bargiota Alexandra

Objective/Design: Gestational diabetes mellitus (GDM) has been associated with serious complications for both the pregnant woman and the newborn. Vitamin B12 is implicated in some important metabolic procedures such as methylation and one carbon cycle and its deficiency can cause serious health problems, such as hyperhomocysteinemia, defective synthesis of neurotransmitters and fatty acids and more. However, it is not known if there is a link between vitamin B12 deficiency and...

ea0041ep303 | Clinical case reports - Pituitary/Adrenal | ECE2016

Diabetes insipidus due to hypophysitis

Vasileiou Agatha , Pappa Dimitra , Filippakopoulos George , Gkountios John , Bargiota Alexandra

Introduction: Hypophysitis is a rare entity, more common in women in pregnancy and the postpartum period and can cause various symptoms such as headache, hypopituitarism and visual disturbances. Stalk thickening and homogeneous enhancement of the gland are the characteristic magnetic resonance imaging (MRI) findings. The diagnosis is based on the clinical picture and on follow up MRIs. Usually involves the anterior pituitary alone, whereas isolated-posterior-pituitary-involvem...

ea0081ep289 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Obesity in adults with type 1 diabetes mellitus and its relation to their eating habits and physical activity

Pappa Dimitra , Barmpa Eleftheria , Christou Maria , Katsaras Ioannis , Tigas Stylianos , Bargiota Alexandra

Introduction: Obesity is rising worldwide and the number overweight or obese patients with type 1 diabetes mellitus (T1DM) is increased and eating habits (EH) and physical activity (PA) play an important role on glycemic control and weight gain. The aim of the present study was to examine the EH and the exercise level in patients with T1DM and their relation to body weight.Methods: 126 patients with T1DM (55/126 males, 71/126 females) attending our outpa...