Endocrine Abstracts

Background: Birt–Hogg–Dubé (BHD) syndrome has been reported to be associated with neoplastic conditions. Its association with thyroid carcinoma has been reported but remains controversial. Here we report the case of a BHD patient with a thyroid papillary carcinoma.Case report: A 47-year-old man presented with asymptomatic facial papules, which had been gradually increasing in number for 6 years. A biopsy was taken from a papule on the nose...

Introduction: Fibrocalculous pancreatic diabetes is an uncommon type of diabetes mellitus due to chronic calcific non-alcoholic pancreatitis. It is associated to several particularities based on glycemic control and the occurrence of degenerative and metabolic complications, in addition to chronic pancreatitis complications.Observation: A 17-year-old male, with no familial history of diabetes and no alcohol consumption, was hospitalized in 1989 for keton...

Nephropathy is a serious complication of Type 1 diabetes mellitus (T1DM) with a grave prognosis after the onset of proteinuria. End stage of renal disease remains the major cause of excess morbidity and premature mortality in patients with T1DM. The aims of the present study were to investigate the prevalence of diabetic nephropathy and to evaluate risk factors for its development among patients developing T1 DM. Seventy six patients with T1DM history over 20 years were includ...

Background: The discovery of a thyroid nodule exposes the problem of the possibility of thyroid cancer. The difficulty of management of this situation is the fact that only the histopathological examination can confirm or refute the malignancy. Fine-needle aspiration (FNA) is used as a diagnostic tool to assess thyroid nodules. The purpose of our study is to correlate the clinical, ultasonographic, the FNA results and final pathology to determine the predictors of malignancy o...

Background: Gigantism indicates excessive secretion of growth hormone (GH) during childhood Pituitary gigantism is very rare and the description of the disease is limited to small series and case reports. Here, we report a case of pituitary gigantism in a child revealed with visual defect.Case report: A 14-year-old boy presented with headache and left visual loss. On examination, he had visual acuity in his right eye of 2/10. His height was 178.0 cm (3 c...

Introduction: Atrial fibrillation (AF) occurs in up to 15% of patients with hyperthyroidism. Although hyperthyroidism is usually regarded as a reversible cause of AF, spontaneous sinus conversion occurs in only 2/3 of patients upon the normalization of T4 levels. The aim of this study was to identify factors associated with persistent atrial fibrillation after restoration of euthyroid state.Methods: We conducted a retrospective study of 13 years. Twenty ...

Bakground: Thyroid-lobectomy is a frequent procedure performed in patients with a variety of thyroid conditions.The aim of this study is to determine the prevalence of post-operative hypothyroidism and the risk factors of hypothyroidism in patients undergoing thyroid-lobectomy.Patients and methods: We retrospectively reviewed patients who underwent a thyroid lobectomy for benign disease from january 2000 to 2014. Patients with known hypothyroidism before...

Background: Hoffmann syndrome is a rare form of hypothyroid myopathy in adults characterized by presence of muscle weakness, stiffness and pseudo-hypertrophy. Here, we report a case of Hoffman syndrome aggravated by statin therapy.Case report: We describe the case of a 60 year old woman with primary hypothyroidism who presented with fatigue, cold intolerance, constipation, exertional breathlessness, progressive proximal muscle weakness and swelling of th...

Introduction: The most common sellar lesions are mainly due to pituitary adenomas, craniopharyngiomas and benign cysts. Rathke’s cleft cyst (RCC) is a developmental sellar or suprasellar cystic lesion, which rarely becomes symptomatic. Here, we present an interesting case of intra sellar RCC, with a presenting feature of acute pituitary apoplexy.Case report: A 39 year old healthy women was referred to the emergency room for sudden headache and fatig...

Introduction: Pituitary insufficiency is a late-onset sequel of cranial irradiation for nasopharyngeal tumors. In a Cancer Survivor Study, 43% of patients treated for nasopharyngeal tumors had one or more endocrinopathies. We aim to characterize the pituitary-related outcomes following cranial radiotherapy for nasopharyngeal tumors over a period of 5 years.Material and methods: The effects of cranial irradiation on hypothalamic-pituitary function were st...