Searchable abstracts of presentations at key conferences in endocrinology

ea0032p974 | Steroid metabolism and action | ECE2013

Effects of food components and the ratio of epitestosterone to testosterone on steroid glucuronidation

Jenkinson Carl , Barker James , Petroczi Andrea , Naughton Declan

The ratio of the glucuronidated epitestosterone (E) and testosterone (T), used in doping tests, is currently under question. The key enzyme involved in E metabolism is UGT2B7 in contrast to T which is mainly metabolised by UGT2B17. Previous results demonstrated that at very high concentrations E acts as a competitive inhibitor to UGT2B17. Similarly, the literature reports competitive inhibition of UGTs by NSAIDS and phenolics that are not substrates of UGT2B17. The aim of this...