ea0038p152 | Neoplasia, cancer and late effects | SFEBES2015
Challis Ben
, Albrechtsen Nicolai
, Bansiya Vishakha
, Burling Keith
, Barker Peter
, Hartmann Bolette
, Gribble Fiona
, O'Rahilly Stephen
, Holst Jens
, Simpson Helen
Context: Pancreatic neuroendocrine tumours (NETs) overexpressing glucagon are associated with phenotypic heterogeneity. Objective: To correlate clinical phenotype with detailed analysis of plasma levels of proglucagon-derived peptides (PGDPs) in subjects with proglucagon-expressing tumours using specific immunoassays and gel filtration profiles to elaborate molecular heterogeneity of PGDPs, before and after somatostatin analogues.Case 1: A 57 year old wo...