Searchable abstracts of presentations at key conferences in endocrinology

ea0011oc55 | Calcium and bone OC49 Novartis Oncology Young Investigator Award | ECE2006

Thyroid hormones stimulate osteoblast differentiation but inhibit mineralization of bone nodules in vitro

Williams AJ , Barnard JC , Bassett JHD , Williams GR

Thyroid hormones stimulate bone formation and linear growth in children. Paradoxically, childhood thyrotoxicosis causes short stature and craniosynostosis due to early closure of the growth plates and skull sutures. In adults, however, thyroid hormone excess increases bone turnover and results in progressive bone loss and osteoporosis. Activating mutations of fibroblast growth factor receptor-3 (FGFR3) cause achondroplastic dwarfism and we have shown that T3 augments FGFR sign...