Searchable abstracts of presentations at key conferences in endocrinology

ea0028p304 | Steroids | SFEBES2012

HSD11B1 promoter binding of the NF-κB p65 subunit in response to TNF-α suppresses 11β-HSD1 expression and activity in C2C12 muscle cells

Doig Craig , Bashir Jamila , Zielinska Agnieszka , Cooper Mark , Stewart Paul , Lavery Gareth

A counter-regulatory rise in GC levels is important to the inflammatory response, that when impaired is associated with high mortality in inflammatory states. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerate’s intracellular glucocorticoids (GC), amplifying their actions, and has been postulated to play a role in the development of inflammation-associated arthritis, obesity and myopathy. Pro-inflammatory cytokines (e.g. TNF-α) increase expressio...