Endocrine Abstracts

Introduction: Risk of vertebral fracture (VFx) is in part independent of bone mineral density (BMD) in primary hyperparathyroidism (PHPT). The aim of this study was to examine whether other factors, including the genotype of common polymorphisms in the calcium-sensing receptor (CASR) gene, are associated with VFx.Patients and methods: In 266 Caucasian PHPT patients, serum calcium, phosphate, creatinine, total alkaline phosphatase, intact PTH, 25-hydroxyv...

Objective: Subclinical hypercortisolism (SH) has been associated with increased prevalence of hypertension, type 2 diabetes mellitus, dyslipidemia, central obesity, osteoporosis and vertebral fractures. We aimed to investigate the accuracy of different SH diagnostic criteria in predicting the concomitant presence of these complications.Patiets: In this retrospective study we evaluated data of 231 patients (120 females and 111 males) affected with adrenal...

Osteopathy is an emerging complication of acromegaly, characterized by increased bone turnover, profound abnormalities in trabecular bone structure and high risk of vertebral fractures (VFs). The therapeutic management of skeletal fragility in acromegaly is a challenge, since the risk of fractures may remain high after the control of acromegaly and the effectiveness of bone-active drugs in this clinical setting is unknown. In this retrospective-multicenter study, we aimed at e...