ea0021p133 | Diabetes and metabolism | SFEBES2009
Baxter Jordan
, Minnion James
, Shilto-Cuenco Joy
, Tan Tricia
, Murphy Kevin
, Ghatei Mohammad
, Bloom Stephen
Pancreatic polypeptide (PP) is a 36 amino acid peptide, secreted from the endocrine pancreas. Previous work has shown that peripheral administration of PP inhibits food intake in rodents and humans. However, PP has a short circulating half-life that limits its use as an anti-obesity agent. Determining the mechanisms involved in the physiological breakdown of PP will allow the rational design of long-acting analogues with greater clinical utility in the treatment of obesity. PP...