Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.06.06 | Reproduction: Female and PCOS | ECE2015

Does finasteride, as well as metformin, improve insulin resistance in PCOS?

Diri Halit , Bayram Fahri , Simsek Yasin

Introduction: The effects of finasteride on insulin resistance and of metformin on hyperandrogenism in patients with polycystic ovary syndrome (PCOS) are not clear. This study therefore compared the effects of finasteride, metformin, and finasteride plus metformin treatments on hormone levels, insulin resistance, and hirsutism score in women with PCOS.Subjects and method: Fifty-two patients with PCOS were randomly assigned to receive finasteride 5 mg/day...

ea0041ep243 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Comparison of hypertriglyceridemic and normotriglyceridemic patients in Konya and in the surrounding area in Turkey

Kaya Ahmet , Turan Elif , Kulaksizoglu Mustafa , Bayram Fahri

Methods: This study, was a cross-sectional survey. Sampling design was based upon multistage probability sampling. Patient with diabetes, hypertension, cardiovascular diseases and any other diseases were excluded from the study. Age and gender were noted. Heights, weights and waist circumference (WC) were measured. BMI was calculated. Blood pressure (BP) was measured. Fasting thyrigliseride levels were evaluated. Patients were divided into two groups according to their triglyc...

ea0041ep421 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

The prevalence of insulin resistance in the Turkish population

Kaya Ahmet , Turan Elif , Uyar Mehmet , Bayram Fahri , Turan Yasar

Introduction: We aimed to investigate the homeostasis model assessment of insulin resistance (HOMA-IR) and relation of HOMA-IR with age, sex and body mass index (BMI) and the prevalence of diabetes in Turkish population of different regions.Methods: Cross-sectional observational study was done in the frame of Turkish prevalence of insulin resistance multicenter study. The study sample consisted of volunteers from seven different regions of Turkey. Weight...

ea0037ep822 | Pituitary: clinical | ECE2015

The effect of gonadotropin treatment on insulin resistance and cardiovascular risk factors in patients with idiopathic hypogonadotropic hypogonadism

Simsek Yasin , Guclu Kenan , Baskol Gulden , Bayram Fahri

Introduction: Idiopathic hypogonadotropic hypogonadism (IHH) is a rare disorder characterised by delayed or absent sexual maturation and infertility associated with inappropriately low gonadotropin and sex steroid levels. Insulin resistance (IR) is defined as an impaired biologic response to both endogenous and exogenous insulin. IR is a common precursor to the development of glucose intolerance, including diabetes, hypertension, and cardiovascular disease. Dyslipidaemia, apol...

ea0022p372 | Endocrine Disruptors | ECE2010

Evaluation of paraxonase activity, malondialdehyde and thiol levels in patients with hypogonadism before and after treatment

Bayram Fahri , Baskol Gulden , Demirkoparan Umit , Gundogan Kursad , Cakir Ilkay

Objectives: Hypogonadism is associated with a higher risk of atherosclerosis and cardiovascular disease, but the mechanisms underlying this association are not yet fully understood. Increased oxidative stress has been associated with development of cardiovascular and cerebrovascular diseases. We aimed to determine serum PON1 activities, an established lipid antioxidant, MDA levels which are end products of lipid peroxidation induced by ROS and thiol groups as an antioxidant fo...

ea0022p374 | Endocrine Disruptors | ECE2010

Paraoxonase is reduced in patients with GH deficiency: a risk factor for atherosclerosis?

Bayram Fahri , Baskol Gulden , Tanriverdi Fatih , Kocer Derya , Cakir Ilkay

Objective: GH deficiency is associated with an increased cardiovascular mortality. Increased oxidative stress has been associated with development of cardiovascular and cerebrovascular diseases. In the present study, we aimed to determine i) serum PON1 activities, an established lipid antioxidant, ii) MDA levels which are end products of lipid peroxidation induced by ROS and iii) thiol groups as an antioxidant for evaluating oxidative stress in patients with GHD before and aft...

ea0022p373 | Endocrine Disruptors | ECE2010

Micronucleus evaluation in mitogen-stimulated lymphocytes of patients with acromegaly

Cakir Ilkay , Hamurcu Zuhal , Donmez-Altuntas Hamiyet , Bitgen Nazmiye , Karaca Zuleyha , Elbuken Gulsah , Bayram Fahri

Aim: Acromegaly is an endocrine disorder characterized by sustained elevation of circulating GH and insulin-like growth factor (IGF1). IGF1 is a potent mitogen and has a role in the transformation of normal cells to malignant cells. Micronucleus (MN) frequency is a biomarker of chromosomal damage, genome instability and cancer risk. Our study aimed to evaluate spontaneous MN frequency by using the cytokinesis block MN assay to determine genetic damage in lymphoytes of patients...

ea0022p759 | Thyroid | ECE2010

Expressions of vascular endothelial growth factor (VEGF), VEGF receptor 1 (VEGF1), insulin like growth factor 1 (IGF1) and IGF1 receptor in differentiated thyroid carcinoma

Karaca Zuleyha , Tanriverdi Fatih , Ozturk Figen , Elbuken Gulsah , Cakir Ilkay , Unluhizarci Kursad , Bayram Fahri , Kelestimur Fahrettin

Objective: Vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor 1 (VEGFR1) are known to be related to thyroid tumorigenesis, but data are limited about their relationship with insulin like growth factor 1 (IGF1) and IGF1 receptor. The aim of this study was to clarify the role of VEGF, VEGFR-1, IGF1 and IGF1 receptor in thyroid tumorigenesis.Methods: We examined 40 patients with differentiated thyroid carcinoma (DTC) a...

ea0014p10 | (1) | ECE2007

Normalization of serum testosterone level alters local GnRH-II and IL-2R mRNA expression in peripheral lymphocytes in patients with idiopathic hypogonadotrophic hypogonadism (IHH)

Tanriverdi Fatih , Akalin Hilal , Caglayan Okay , Demirkoparan Umit , Ozkul Yusuf , Dundar Munis , Bayram Fahri , Kelestimur Fahrettin

Although the existence of the interaction between sex steroids and immune system is well known, the mechanisms of this interaction are still unclear. Recently a second form of GnRH (GnRH-II) has been described in human, which is significantly expressed in immune tissues suggesting a potential function. In a recent in-vitro study it has been demonstrated that GnRH-II decreases local expression of IL-2R in peripheral lymphocytes (1). However in-vivo interactions of...