Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.06.06 | Reproduction: Female and PCOS | ECE2015

Does finasteride, as well as metformin, improve insulin resistance in PCOS?

Diri Halit , Bayram Fahri , Simsek Yasin

Introduction: The effects of finasteride on insulin resistance and of metformin on hyperandrogenism in patients with polycystic ovary syndrome (PCOS) are not clear. This study therefore compared the effects of finasteride, metformin, and finasteride plus metformin treatments on hormone levels, insulin resistance, and hirsutism score in women with PCOS.Subjects and method: Fifty-two patients with PCOS were randomly assigned to receive finasteride 5 mg/day...

ea0041ep243 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Comparison of hypertriglyceridemic and normotriglyceridemic patients in Konya and in the surrounding area in Turkey

Kaya Ahmet , Turan Elif , Kulaksizoglu Mustafa , Bayram Fahri

Methods: This study, was a cross-sectional survey. Sampling design was based upon multistage probability sampling. Patient with diabetes, hypertension, cardiovascular diseases and any other diseases were excluded from the study. Age and gender were noted. Heights, weights and waist circumference (WC) were measured. BMI was calculated. Blood pressure (BP) was measured. Fasting thyrigliseride levels were evaluated. Patients were divided into two groups according to their triglyc...

ea0041ep421 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

The prevalence of insulin resistance in the Turkish population

Kaya Ahmet , Turan Elif , Uyar Mehmet , Bayram Fahri , Turan Yasar

Introduction: We aimed to investigate the homeostasis model assessment of insulin resistance (HOMA-IR) and relation of HOMA-IR with age, sex and body mass index (BMI) and the prevalence of diabetes in Turkish population of different regions.Methods: Cross-sectional observational study was done in the frame of Turkish prevalence of insulin resistance multicenter study. The study sample consisted of volunteers from seven different regions of Turkey. Weight...

ea0041ep547 | Diabetes therapy | ECE2016

The effects of vitamin D on advanced glycation end-products in prediabetic and type 2 diabetic patients with vitamin D deficiency

Tekin Bahar , Bayram F. Buket , Yavuz Dilek Gogas

Aim: There is strong evidence regarding vitamin D being a risk factor for Type 2 Diabetes Mellitus (T2DM). In this study, we aimed to investigate the effects of vitamin D on advanced glycation end-products in prediabetic and type 2 diabetic patients with vitamin D deficiency.Methods: Forty type 2 diabetic patients, 40 prediabetic patients and 40 healthy controls with the levels of vitamin D <20 ng/ml were included in the study. All three groups were ...

ea0041ep888 | Pituitary - Clinical | ECE2016

Evaluation of endothelial function and insulin sensitivity in patients with prolactinoma

Buket Bayram F , Tekin Bahar , Gogas Yavuz Dilek

Objective: Hyperprolactinemia has been reported to be associated with endothelial dysfunction, abnormalities of carbohydrate metabolism and insulin sensitivity. The aim of this study was to evaluate carbohydrate metabolism and endothelial function of our patients in outpatient clinics.Material and methods: In this cross-sectional study, currently or previously treated 87 hyperprolactinemic patients with PRL-secreting adenoma (fifty four with microadenoma...

ea0037ep822 | Pituitary: clinical | ECE2015

The effect of gonadotropin treatment on insulin resistance and cardiovascular risk factors in patients with idiopathic hypogonadotropic hypogonadism

Simsek Yasin , Guclu Kenan , Baskol Gulden , Bayram Fahri

Introduction: Idiopathic hypogonadotropic hypogonadism (IHH) is a rare disorder characterised by delayed or absent sexual maturation and infertility associated with inappropriately low gonadotropin and sex steroid levels. Insulin resistance (IR) is defined as an impaired biologic response to both endogenous and exogenous insulin. IR is a common precursor to the development of glucose intolerance, including diabetes, hypertension, and cardiovascular disease. Dyslipidaemia, apol...

ea0022p372 | Endocrine Disruptors | ECE2010

Evaluation of paraxonase activity, malondialdehyde and thiol levels in patients with hypogonadism before and after treatment

Bayram Fahri , Baskol Gulden , Demirkoparan Umit , Gundogan Kursad , Cakir Ilkay

Objectives: Hypogonadism is associated with a higher risk of atherosclerosis and cardiovascular disease, but the mechanisms underlying this association are not yet fully understood. Increased oxidative stress has been associated with development of cardiovascular and cerebrovascular diseases. We aimed to determine serum PON1 activities, an established lipid antioxidant, MDA levels which are end products of lipid peroxidation induced by ROS and thiol groups as an antioxidant fo...

ea0022p374 | Endocrine Disruptors | ECE2010

Paraoxonase is reduced in patients with GH deficiency: a risk factor for atherosclerosis?

Bayram Fahri , Baskol Gulden , Tanriverdi Fatih , Kocer Derya , Cakir Ilkay

Objective: GH deficiency is associated with an increased cardiovascular mortality. Increased oxidative stress has been associated with development of cardiovascular and cerebrovascular diseases. In the present study, we aimed to determine i) serum PON1 activities, an established lipid antioxidant, ii) MDA levels which are end products of lipid peroxidation induced by ROS and iii) thiol groups as an antioxidant for evaluating oxidative stress in patients with GHD before and aft...

ea0022p549 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

IGF(CA)19 and IGFBP-3-202A/C gene polymorphism in patients with acromegaly

Akin Fulya , Turgut Sebahat , Cirak Bayram , Kursunluoglu Raziye

Aims: We aimed to investigate IGF1 and IGFBP3 gene polymorphisms in patients with acromegaly.Methods: We included 34 patients with acromegaly and 37 healthy subjects to study. At baseline examinations, antropometric measurements were done. Genomic DNA from the patients and controls were prepared. Serum, glucose, insulin, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, GH, IGF1 and IGFBP3 levels of subjects were analyzed.<p class="a...

ea0073aep643 | Thyroid | ECE2021

Assessment of hearing impairment in adult patients with euthyroid Hashimoto’s thyroiditis

Ömercan Topaloğlu , BayramŞahin

IntroductionHearing loss may be associated with autoimmune diseases, but it was less studied in Hashimoto’s thyroiditis (HT). We aimed to evaluate hearing impairment by audiometric assessments in adults with euthyroid HT.Materials and MethodsAdult patients with euthyroid HT (normal thyroid functions, positive AntiTPO/AntiTg and sonographic findings) were compared with controls. We excluded pregnant or ol...