ea0011p470 | Endocrine tumours and neoplasia | ECE2006
Hahner S
, Beidinger E
, Stuermer A
, Koschker AC
, Weismann D
, Fassnacht M
, Allolio B
Treatment of adrenocortical carcinoma (ACC) is still unsatisfactory. As IGF-II and IGF-I receptor are frequently overexpressed in human ACC and inhibitors of the IGF system are currently under preclinical investigation, interference with IGF-signaling might have an additive effect in antitumour treatment. We have therefore analyzed several cytotoxic agents (etoposide, doxorubicine, cisplatin, streptocozin; 0.01100 μM) on adrenal cell proliferation in vitro an...