Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep511 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

HNF1A MODY revealed by recurrent hypoglycemia

Belaid Rym , Sebaa Rabah Ben , Alfred Penfornis

Introduction: Hepatocyte nuclear factor 1A MODY (HNF1A-MODY) is the most common form of Maturity-onset diabetes of the young (MODY) diagnosed in adults. It is caused by heterozygous mutations in the HNF1A gene and is associated with progressive β-cell failure and increasing hyperglycemia due to reduced insulin secretion. HNF1A-MODY is characterized by a large phenotypic variability. We herein report the case of a 40-year-old diabetic woman who was identified as h...

ea0081ep993 | Thyroid | ECE2022

Methimazole-induced cholestatic jaundice

Chayma Soltani , Belaid Rym , Naourez Abid , Lamine Hamzaoui , Raja Amri

Introduction: Methimazole is a widely prescribed antithyroid drug for the treatment of hyperthyroidism with a few adverse effects generally well-tolerated. However, methimazole-induced cholestatic jaundice (CJ) is a rare but serious adverse reaction. Herein we report a rare case of methimazole-induced CJ in a woman with hyperthyroidism.Case report: A 57-years-old women presented to our endocrinology department with a 2-week history of asthenia, insomnia,...

ea0081ep994 | Thyroid | ECE2022

Auto-immune polyglandular syndrome type IIIa: a case report

Belaid Rym , Chayma Soltani , Wafa Garbouj , Zeineb Alaya , Raja Amri

Introduction: Autoimmune polyglandular syndromes (APS) are rare polyendocrinopathies characterized by the failure of several endocrine glands as well as nonendocrine organs, caused by an immune-mediated destruction of endocrine tissues. The type IIIa APS is the association of thyroid autoimmune diseases, type 1 diabetes mellitus and other autoimmune conditions excluding Addison’s disease and hypoparathyroidism. Herein, we report the case of autoimmune hypothyroidism assoc...

ea0056p1015 | Thyroid (non-cancer) | ECE2018

An eleven–year–old girl presenting with Graves’ ophtalmopathy

Belaid Rym , Jaidane Amel , Oueslati Insaf , Zouaoui Chadia , Ouertani Haroun

Introduction: Graves’ ophthalmopathy (GO) is an autoimmune disorder affecting the retro-orbital tissues. It represents the main extra- thyroidal expression of Graves’ disease (GD). In children, GO is less common and less severe than in adults. Herein we report a case of GO in a child.Case report: An 11-year-old girl with family history of autoimmune thyroid disease was referred to our department for evaluation of suspected hyperthyroidism. She ...

ea0056p1118 | Thyroid cancer | ECE2018

Mixed medullary–papillary carcinoma of the thyroid: a case report

Belaid Rym , Jaidane Amel , Oueslati Insaf , Zouaoui Chadia , Ouertani Haroun

Introduction: The coexistence of two types of tumors of different origins in the same thyroid is a rare phenomenon. Its etiopathogenesis remains unknown. We report the case of a mixed papillary and medullary carcinoma of the thyroid revealed by a compressive goiter.Case report: A 70-year old woman with a history of right lobo-isthmusectomy for a toxic solitary adenoma, presented 30 years later with a chief complaint of a cervical mass accompanied by diff...

ea0081ep97 | Adrenal and Cardiovascular Endocrinology | ECE2022

Adrenal insufficiency revealed during a septic shock

Belaid Rym , Bouzid Anissa Ben , Abdelaziz Nada Ban , Abid Naourez , Amri Raja

Introduction: Acute adrenal insufficiency (AAI) is a rare but life-threatening condition. It may occur in 50 to 60% of septic shocks (SS). Its diagnosis can be difficult as symptoms are sometimes nonspecific. Herein, we report the case of a female patient with an AAI revealed during SS. A 30-year-old woman with a history of celiac disease since the age of 25 on a gluten-free diet, presented to the emergency department with abdominal pain, vomiting, fever and profound asthenia...

ea0081ep995 | Thyroid | ECE2022

Coexisting grave’s disease and coeliac disease in an adolescent with down’s syndrome

Bouzid Anissa Ben , Belaid Rym , Abdelaziz Nada Ben , Abid Naourez , Amri Raja

Introduction: Trisomy 21 is the most common chromosomal disorder. It is associated with an increased risk of endocrinopathy particularly thyroid gland disorders. This is frequently a compensated hypothyroidism. Hyperthyroidism is rare. We report the case of an adolescent with Down’s syndrome and celiac disease who presented with subclinical hyperthyroidism.Case report: It was a 15-year-old female from a non-consanguineous marriage with a history of ...

ea0063p363 | Thyroid 1 | ECE2019

Analysis of clinical and biological predictors of malignancy in thyroid nodules

Belaid Rym , Oueslati Ibtissem , Chaker Fatma , Rejeb Ons , Grira Wafa , Yazidi Meriem , Chihaoui Melika

Background: Thyroid nodules are the most common thyroid disease. In the majority of cases, they are benign. However, 5 to 15% of nodules are cancer. The aim of our study was to determine the clinical and biological predictive factors of malignancy in thyroid nodules.Methods: We performed a retrospective descriptive study including 100 patients collected in the endocrinology department of La Rabta hospital over 18 year old period (2000–2018). All the...

ea0063p364 | Thyroid 1 | ECE2019

Sensitivity and specificity of ultrasound features in predicting malignant thyroid nodules

Belaid Rym , Oueslati Ibtissem , Grira Wafa , Rejeb Ons , Yazidi Meriem , Chaker Fatma , Chihaoui Melika

Background: Ultrasound is valuable for identifying many malignant or potentially malignant thyroid nodules. The aim of this study was to evaluate the efficacy of ultrasonographic (US) features in predicting the malignancy of thyroid nodules in a group of Tunisian patients.Methods: We conducted a retrospective descriptive study including 100 patients collected in the endocrinology department of La Rabta hospital. All these patients underwent thyroidectomy...

ea0049ep147 | Endocrine tumours and neoplasia | ECE2017

Clinical and hormonal characteristics of adrenal incidentalomas

Belaid Rym , Oueslati Ibtissem , Mimita Wafa , Khiari Karima , Mchirgui Nadia , Abdallah Nejib Ben

Introduction: Widespread use of abdominal imaging has led to the identification of an increasing number of adrenal incidentalomas (AI) in the last decades. Causes of these adrenal masses are multiple.Aim: The aim of this study was to investigate the clinical and hormonal characteristics of AI.Materials and methods: The study was a retrospective monocentric analysis of 44 patients with AI who underwent radiographic and endocrine eva...