Searchable abstracts of presentations at key conferences in endocrinology

ea0035oc12.4 | Pituitary Basic | ECE2014

Identification and characterization of pituitary adenoma stem-like cells in human non functioning pituitary adenomas

Giardino Elena , Peverelli Erika , Treppiedi Donatella , Belicchi Marzia , Meregalli Mirella , Spada Anna , Torrente Yvan , Mantovani Giovanna

Several studies support the existence of multipotent stem/progenitor cells in the adult pituitary, whereas the presence of stem cell in pituitary tumors and their role in pituitary tumorigenesis are still on debate. Aim of this study was to identify and characterize stem-like cells in non-functioning pituitary adenomas (NFPAs). To this purpose primary cell cultures from 25 NFPAs were grown in culture conditions that favored stem cell growth (EGF, bFGF and B27 containing medium...

ea0016oc4.6 | Bone and adrenal | ECE2008

Isolation and characterization of cells coexpressing endothelial progenitors and parathyroid specific genes from human adult normal and tumoral parathyroids

Corbetta Sabrina , Belicchi Marzia , Pisati Federica , Meregalli Mirella , Eller-Vainicher Cristina , Vicentini Leonardo , Beck-Peccoz Paolo , Spada Anna

A peculiar characteristic of parathyroid tissue is the ability to spontaneously induce angiogenesis, to proliferate and to secrete PTH when autotransplanted in patients undergoing total parathyroidectomy. Since stem/progenitor cells have been involved in the process of tissue regeneration, we searched for putative parathyroid progenitors from human normal and tumoral parathyroids. By immunohistochemistry, FACS analysis and cell culture we identified parathyroid cells positive ...