Searchable abstracts of presentations at key conferences in endocrinology

ea0021p152 | Diabetes and metabolism | SFEBES2009

At high dietary fat levels, dietary fish–oil may enhance metabolic efficiency but may favour a reduction in the deposition of adipose tissue

Sleeth Michelle , Thompson Emily , Anastasovska Jelena , Bell Jimmy , Frost Gary

Background: Obesity is the excessive accumulation of adipose tissue to the extent that health may be impaired. Determination of the mechanisms governing adipose deposition and body weight regulation are now a scientific priority. High dietary fat intake is generally considered to be a factor in obesity’s multi-factorial aetiology and the metabolic syndrome. Yet not all dietary fats appear to be obese genic to the same degree.Objective: To study the ...

ea0015p135 | Diabetes, metabolism and cardiovascular | SFEBES2008

Non-alcoholic fatty liver disease and its relationship with Type 2 diabetes

Forbes Shareen , Godsland Ian , Bell Jimmy , Thomas Louise , Taylor-Robinson Simon , Johnston Desmond , Walker Brian

Introduction: It is not known if non-alcoholic fatty liver disease (NAFLD) predates type 2 diabetes. We will study the prevalence of NAFLD in women with previous gestational diabetes (GDM), a population at ≥60% risk for the development of type 2 diabetes, while glucose tolerance is non-diabetic. It is not known if hepatic fat accumulation in NAFLD is disproportionate to fat accumulation in other tissues. We aim to study the association between fat in the liver and in tis...

ea0015p204 | Neuroendocrinology and behaviour | SFEBES2008

Increased desire for food when fasted is associated with increased activation of the ventral striatum, insula and amygdala in humans

Goldstone Anthony P , de Hernandez Christina Prechtl , Muhammed Kinan , Bell Gabriel , Durighel Giuliana , Hughes Emer , Waldman Adam D , Bell Jimmy D

Using functional MRI, we examined how regional brain activity varies with nutritional state when viewing food pictures of different caloric density and appeal.Eighteen non-obese healthy volunteers (BMI 22.2±0.5 kg/m2, age range 19–36 years, 8 male) were studied on 2 separate mornings after an overnight fast (mean±S.E.M. 15.5±0.3 h) or when fed (1.2±0.1 h after breakfast, food intake 45±4% of estimat...

ea0013oc27 | Neuroendocrinology, reproduction and cardiovascular | SFEBES2007

Manganese-enhanced MRI demonstrates that oxyntomodulin and GLP-1 affect neuronal activity in distinct regions of the brain

Chaudhri Owais , Parkinson James , Herlihy Amy , Salem Victoria , Kuo Yu-Ting , Bell Jimmy , So Po-Wah , Dhillo Waljit , Stanley Sarah , Ghatei Mohammad , Bloom Steve

The rise in the prevalence of obesity has imparted urgency to the study of the mechanisms of appetite regulation. Oxyntomodulin (OXM) and glucagon-like peptide-1 (GLP-1) are anorexigenic gut hormones thought to act via the same receptor. There is an increasing body of evidence, however, that they may act via distinct pathways. Magnetic resonance imaging (MRI) is increasingly being used as a tool for tracking changes in neuronal activity in vivo through time. Manganese-e...

ea0038ecp1.2 | (1) | SFEBES2015

Kisspeptin- A ‘key regulator’ of reproductive physiology, integrating limbic circuits with the regulation of reproductive hormones

Comninos Alexander , Anastasovska Jelena , Shah Amar , Wall Matthew , Jayasena Channa , Li Xiaofeng , Abbara Ali , Narayanaswamy Shaku , Nijher Gurjinder , Izzi-Engbeaya Chioma , Demetriou Lysia , Clarke Sophie , Ghatei Mohammad , Bell Jimmy , Matthews Paul , Bloom Stephen , O'Byrne Kevin , Dhillo Waljit

Kisspeptin is a recently identified reproductive hormone which serves as a crucial activator of the Hypothalamic–Pituitary–Gonadal (HPG) axis via stimulation of GnRH neurones. We have previously observed that a single kisspeptin injection increases LH pulsatility while twice daily kisspeptin injections can even advance the menstrual cycle. Furthermore, we have demonstrated that kisspeptin restores LH pulsatility in women with hypothalamic amenorrhoea and can potently...