Searchable abstracts of presentations at key conferences in endocrinology

ea0014oc1.7 | Thyroid clinical | ECE2007

Pregnant women on thyroxine substitution are often dysregulated in early pregnancy

Hallengren Bengt , Lantz Mikael , Andreasson Bengt , Grennert Lars

Background: Thyroid hormones are important for normal fetal development. The aim of this prospective study was to explore whether thyroxine treated pregnant women with hypothyroidism are adequately thyroxine substituted during pregnancy.Material and method: During the years 1997–2002 119 pregnancies in 101 females with thyroid diseases were followed at the Department of Endocrinology. The diagnoses were autoimmune thyroiditis (AIT) with or without h...

ea0032p1010 | Thyroid (non-cancer) | ECE2013

Increased TRAb and/or low anti-TPO titers at diagnosis of Graves' disease (GD) are associated with an increased risk of developing ophthalmopathy after onset of GD

Lantz Mikael , Planck Tereza , Asman Peter , Hallengren Bengt

Objective: Patients with low thyroid peroxidase antibodies (anti-TPO) and increased TSH-receptor antibodies (TRAb) at diagnosis of Graves’ disease (GD) have been suggested to have an increased risk to develop Graves’ ophthalmopathy (GO). The aim was to evaluate if GO development can be predicted.Design: Observational study with registration of possible GD and GO risk factors.Methods: Three hundred and ninety nine patients...

ea0037gp.20.01 | Pituitary – Hypopituitarism | ECE2015

Reduced mortality due to malignant neoplasms in patients receiving long-term GH replacement therapy – a Swedish study based on more than 4000 patient-years

Olsson Daniel S , Nilsson Anna G , Trimpou Penelope , Bengtsson Bengt-AEke , Andersson Eva , Johannsson Gudmundur

Patients with hypopituitarism and untreated growth hormone (GH) deficiency have excess mortality. GH replacement therapy (GHRT) has many beneficial effects, but its impact on mortality has not been proven and there are still safety concerns regarding the potential cancer risk. We have therefore studied the mortality in non-functioning pituitary adenoma (NFPA) patients with and without GHRT. Only patients with NFPA were studied in order to eliminate the influence of the aetiolo...

ea0056gp2 | Acromegaly | ECE2018

Retinal vessel abnormalities in acromegaly

Fuchtbauer Laila , Olsson Daniel S , Norrman Lise-Lott , Bengtsson Bengt-AEke , Hellstrom Ann , Johannsson Gudmundur

Growth hormone (GH) and insulin like growth factor 1 (IGF-I) modulate and stimulate angiogenesis and endothelial function. Excess of GH, as in acromegaly, is associated with cardiovascular morbidity and mortality, which is reversible after normalization of IGF-I and GH. Diabetes mellitus (DM) is a common comorbidity in acromegaly, but the prevalence of diabetes retinopathy in patients with acromegaly is unknown. Also, the roles of GH and IGF-I in diabetes retinopathy are not f...

ea0014p245 | (1) | ECE2007

Growth hormone Reduces Inflammation in Postmenopausal Women with Abdominal Obesity: a 12-month randomized placebo-controlled trial

Franco Celina , Andersson Björn , Lönn Lars , Bengtsson Bengt-Æke , Svensson Johan , Johannsson Gudmundur

Context: Abdominally obese individuals have relative hyposomatotropism, elevated serum markers of inflammation, and increased risk of cardiovascular disease (CVD).Objective: The aim was to study the effect of GH treatment on serum levels of inflammatory markers and vascular adhesion molecules in postmenopausal women with abdominal obesity.Design: Forty postmenopausal women aged 51–63 yrs with abdominal obesity received GH (0.6...