ea0038oc3.5 | Steroids and adrenal | SFEBES2015
, Birnie Matthew
, Flynn Benjamin
, Kershaw Yvonne
, Lightman Stafford
Endogenous glucocorticoids are secreted in hourly pulses, establishing a characteristic ultradian rhythm. Accordingly, the glucocorticoid receptor (GR) is activated in distinct pulses, causing target-gene pulsing. In contrast, constant glucocorticoid treatment causes aberrant target-gene overexpression in cell culture models, however this has not yet been described in vivo. Therefore, here we assess the effect of altering the glucocorticoid ultradian pattern on transc...