Searchable abstracts of presentations at key conferences in endocrinology

ea0063p760 | Thyroid 2 | ECE2019

NMR-measured subfractions of HDL-cholesterol through thyroid function spectrum

Janovsky Carolina Castro Porto Silva , Bittencourt Marcio Sommer , Goulart Alessandra , Lotufo Paulo A , Bensenor Isabela M

Thyroid dysfunction has been traditionally related to several lipid abnormalities. Indeed, even within the normal range of thyroid-stimulating hormone (TSH) values, a linear increase in total cholesterol, low-density lipoprotein cholesterol and triglycerides and a linear decrease in high-density lipoprotein cholesterol (HDL-C) levels has been observed with increasing TSH. With respect to serum high-density lipoprotein (HDL) cholesterol concentrations, high, normal, or low valu...

ea0084op-06-28 | Oral Session 6: Hypothyroidism | ETA2022

The optimal ranges of thyroid function based on the risk of cardiovascular disease and mortality: an individual participant data meta-analysis

Xu Yanning , Derakhshan Arash , Wildisen Lea , Hysaj Ola , Iacoviello Massimo , Ceresini Graziano , Ferrucci Luigi , Iervasi Giorgio , Pingitore Alessandro , Vaes Bert , Gussekloo Jacobijn , Medici Marco , Galesloot Tessel , P. F. Dullaart Robin , J.L. Bakker Stephan , Wouter Jukema J. , Trompet Stella , Westendorp Rudi , Ittermann Till , Volzke Henry , Dorr Marcus , Schmidt Borge , Fuhrer Dagmar , J. Wareham Nicholas , Boelaert Kristien , Razvi Salman , P. J. Vanderpump Mark , Muendlein Axel , Drexel Heinz , Bensenor Isabela , Sgarbi Jose , C. Bauer Douglas , A. Fink Howard , M. Rhee Connie , Azizi Fereidoun , Imaizumi Misa , B. Yeap Bu , Hankey Graeme , J. Brown Suzanne , P. Walsh John , Korevaar Tim , Rodondi Nicolas , R. Cappola Anne , Peeters Robin , Chaker Layal , the Thyroid Studies Collaboration for

Background and Objective: Thyroid function reference ranges are statistically defined by the 2.5th and 97.5th percentiles, which do not account for potential risk of clinical outcomes. We aimed to define the optimal ranges of thyroid-stimulating hormone (TSH) and free thyroxine (FT4), based on the risk of cardiovascular disease (CVD) and mortality.Methods: We performed an individual-participant data analysis and identified prospecti...